Nucleosides
Apexbio Technology LLC 6-Thio-dG 789-61-7 5mg
6-Thio-2 -deoxyguanosine (6-Thio-dG CAS 789-61-7) is a nucleoside analogue that functions as a telomerase-mediated telomere targeting agent In telomerase-positive cancer cells 6-Thio-dG is incorporated into telomeric DNA inducing rapid telomere dysfunction independent of direct telomerase inhibition which leads to growth arrest and cell death In vitro cancer cell lines exhibit IC50 values ranging from 0 7 to 2 9 M indicating high sensitivity to the compound Normal cells with telomerase-silent status show minimal morphological effects upon 6-Thio-dG exposure In vivo 6-Thio-dG administration inhibits tumor growth and reduces proliferation markers in xenograft models The compound is valuable for investigating telomere biology and as a tool to evaluate telomerase-dependent therapeutic strategies in cancer research
Cayman Chemical 6-thIo-2-DeoxygunosIn 10mg
A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
Cayman Chemical 6-thIo-2-DeoxygunosIn 25mg
A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
Chem-Impex International, Inc. 2'-Deoxycytidine | 951-77-9 | MFCD00006547 | 1G
2'-Deoxycytidine, 951-77-9, MFCD00006547, 1G
Cayman Chemical Pseudouridine 10mg
The C-5 glycoside isomer of uridine; formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme; found in tRNAs from bacteria, archaea, and eukaryotes; reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner
Cayman Chemical Pseudouridine 25mg
The C-5 glycoside isomer of uridine; formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme; found in tRNAs from bacteria, archaea, and eukaryotes; reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner
Biotium BrdU (5-Bromo-2'-Deoxyuridine)
BrdU (5-Bromo-2′-deoxyuridine) can be incorporated into DNA during cell division and subsequently detected by a BrdU antibody. The probe is useful for studying cell-cycle kinetics. Properties: White solid soluble in DMSO; Store at -20⁰C; C9H11BrN2O5; MW: 307.10; [59-14-3].
Medchemexpress LLC 4'-azidocytidine analogue | 876708-01-9 | ≥95.0% | 285.21 | C9H11N5O6 | 10 MG
Nucleoside-Analog-2 is a 4'-azidocytidine analogue that inhibits Hepatitis C virus replication and is supplied as a click-chemistry reagent. It contains an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) with suitable partners.
- 4'-azidocytidine analogue active against HCV replication.
- Contains an azide group for CuAAC and SPAAC click chemistry.
- Purity ≥95.0% and molecular weight 285.21 g/mol.
- Available as solid in multiple mg sizes and as 10 mM solution in DMSO.
- Powder storage: -20°C for 3 years or 4°C for 2 years; solution storage: -80°C for 2 years.
Sigma Aldrich Fine Chemicals Biosciences 7-Deaza-2'-deoxyguanosine 5'-triphosphate lithium salt 10 mM in H2O | 101515-08-6 | MFCD00171614 | 0.5UMO
7-Deaza-2'-deoxyguanosine 5'-triphosphate lithium salt 10 mM in H2O | Mol Wt: 506.19 | 101515-08-6 | MFCD00171614 | 0.5UMO
Sigma Aldrich Fine Chemicals Biosciences Cytidine 5'-diphosphocholine sodium salt dihydrate ~98%, from yeast, solid | 33818-15-4 | MFCD00150508 | 500MG
Cytidine 5'-diphosphocholine sodium salt dihydrate ~98%, from yeast, solid | Purity: ~98% | Mol Wt: 546.34 | 33818-15-4 | MFCD00150508 | 500MG
Medchemexpress LLC 5-fluorocytidine | 2341-22-2 | MFCD00210953 | 97.0% | 261.21 g/mol | C9H12FN3O5 | 1 G
5-fluorocytidine is a fluorinated cytidine nucleoside that inhibits maturation of the 45S ribosomal RNA precursor and is provided as a characterized research reagent with storage and safety guidance from product datasheets and SDS.
- Fluorinated cytidine nucleoside.
- Inhibits maturation of the 45S ribosomal RNA precursor.
- Molecular formula C9H12FN3O5.
- Molecular weight 261.21 g/mol.
- Storage: 4°C under nitrogen; in solvent: -80°C for 6 months, -20°C for 1 month.
Sigma Aldrich Fine Chemicals Biosciences Pseudouridine 9825MG
Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite. Pseudouridine is found in all species and in all classes of RNA except mRNA. It is formed by enzymes called pseudouridine synthases which post-transcriptionally isomerize specific uridine residues in RNA.
Medchemexpress LLC HY-101969 5mg Medchemexpress, Pseudothymidine CAS:65358-15-8 Purity:>98%
Medchemexpress, HY-101969 5mg Pseudothymidine CAS:65358-15-8 Pseudothymidine is a C-nucleoside analog of thymidine. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.