RNAi Controls
Genscript Corporation NKG2D/CD314 hFc Chimera Flag
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands Human NKG2D is expressed on CD8 alpha beta T cells gamma T cells NK cells and NKT cells
Genscript Corporation TNFRSF12A/TWEAKR hFc Chimera
Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer in addition PPAR signaling pathway insulin signaling pathway mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A
Genscript Corporation CD47 hFc Chimera Human
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
Genscript Corporation CD200 R1/CRTR2 hFc Chimera Hu
CD200Fc a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region regulates immune responses following engagement of a cell surface receptor CD200R expressed on cells of the myeloid and T cell lineage A recent report focused attention on a family of CD200Rs but concluded that only one member used CD200 as its ligand
Genscript Corporation SLAMF7/CRACC/CD319 hFc Chimera
CD2-like receptor activating cytotoxic cells (CRACC) also known as CS1 novel Ly9 SLAMF7 and CD319 is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response
Genscript Corporation CD160 hFc Chimera Mouse
CD160 (also Natural killer cell receptor BY55) is a 27 30 kDa member of the Ig superfamily In human it is expressed principally on nonmyeloid hematopoietic cells CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation Exists as a GPI-anchored and as a transmembrane form each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells
Genscript Corporation FGFR2 beta IIIb hFc Chimera
Four distinct genes encoding closely related FGF receptors FGFR1-4 are known All four genes for FGFRs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid-box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain Multiple forms of FGFR1-3 are generated by alternative splicing of the mRNAs A frequent splicing event involving FGFR1 and 2 results in receptors containing all three Ig domains referred to as the alpha isoform or only IgII and IgIII referred to as the beta isoform
Genscript Corporation TNFRSF12A/TWEAKR hFc Chimera
Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer in addition PPAR signaling pathway insulin signaling pathway mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A
Genscript Corporation CD161 hFc Chimera Human
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment
Genscript Corporation CD3ECD3D hFc Chimera Biotin
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD3ECD3D hFc Chimera Human
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD3ECD3D hFc Chimera Biotin
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation ROR1 hFc Chimera Human/Cynomo
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1) is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains highly related to those of the Trk-family receptor tyrosine kinases and by the extracellular Frizzled-like cysteine-rich domains and kringle domains which are common to receptors of the Wnt family members
Genscript Corporation ROR1 hFc Chimera Human/Cynomo
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1) is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains highly related to those of the Trk-family receptor tyrosine kinases and by the extracellular Frizzled-like cysteine-rich domains and kringle domains which are common to receptors of the Wnt family members
Genscript Corporation CD47 hFc Chimera Human
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers