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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
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The S-PLEX Human CTLA-4 Kit by Meso Scale Diagnostics is a multiplex immunoassay kit that enables the simultaneous measurement of CTLA-4 in human serum plasma and cell culture supernatants The kit contains a 96-well plate coated with capture antibodies detection antibodies Read Buffer Diluent 2 Calibrator Blend and controls The electrochemiluminescent assay has a typical sensitivity of 0 3 pg/mL and an assay range from 0 3-2500 pg/mL The kit is for research use only and not for diagnostic procedures It allows high-throughput quantitative analysis of CTLA-4 with low sample volume requirements
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DSG Crosslinker (disuccinimidyl glutarate) is a homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker used as a cleavable ADC linker for antibody-drug conjugation and for amine-to-amine coupling in bioconjugation workflows.
Homobifunctional NHS ester for amine coupling.
Molecular weight 326.26 g/mol and formula C13H14N2O8.
High purity (98.0%) suitable for research use.
Soluble in DMSO (100 mg/mL) with ultrasonic assistance.
Powder stable at -20°C for extended storage.
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The protein encoded by this gene is a member of the dual specificity protein kinase family which acts as a mitogen-activated protein (MAP) kinase kinase MAP kinases also known as extracellular signal-regulated kinases (ERKs) act as an integration point for multiple biochemical signals This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals As an essential component of MAP kinase signal transduction pathway this kinase is involved in many cellular processes such as proliferation differentiation transcription regulation and development [provided by RefSeq Jul 2008]
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Dyneins are a group of microtubule-activated ATPases that function as molecular motors They are divided into two subgroups of axonemal and cytoplasmic dyneins The cytoplasmic dyneins function in intracellular motility including retrograde axonal transport protein sorting organelle movement and spindle dynamics Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains This gene encodes a member of the cytoplasmic dynein heavy chain family
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The protein encoded by this gene is a member of the thiol-specific antioxidant protein family This protein is a bifunctional enzyme with two distinct active sites It is involved in redox regulation of the cell it can reduce H(2)O(2) and short chain organic fatty acid and phospholipid hydroperoxides It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury
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