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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
MW 398.4 Da, Purity >99%. Selective cell-permeable inhibitor of casein kinase 1 (CK1) . (IC₅₀ values are 0.3 (CK1), 0.5 (ALK5), 9.1 (PKd1) and 5.8 μM (p38αMAPK)). Displays selectivity over many other protein kinases.
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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference The encoded protein is highly basic and contains a PAZ domain and a PIWI domain It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing Multiple transcript variants encoding different isoforms have been found for this gene
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