Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
Mutations that cause a loss or reduction in gene function can result in the progression to cancer, usually in combination with other genetic changes. Tumor suppressor genes, or anti-oncogenes, can protect cells on the path to becoming cancerous.
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Mutations that cause a loss or reduction in gene function can result in the progression to cancer, usually in combination with other genetic changes. Tumor suppressor genes, or anti-oncogenes, can protect cells on the path to becoming cancerous.
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Ambion™ Silencer™ SelectGAPDH Positive Control siRNA, In Vivo Ready is extensively validated and an ideal control for many aspects of an siRNA experiment.
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The nuclear hormone receptor gene family includes receptors for thyroid and steroid hormones, retinoids and vitamin D, as well as receptors of unknown ligands.
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The Silencer™ Human Membrane Trafficking siRNA Library is designed for researchers targeting proteins known or predicted to participate in membrane trafficking or remodeling.
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DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations.
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The Silencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™ Silencer Select highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones.
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