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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
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This gene belongs to the protein arginine methyltransferase (PRMT) family The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification A related pseudogene is located on chromosome 9
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The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death
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