siRNA
HORIZON DISCOVERY BIOSCIENCES LIMITED ON-TARGETPLUS NON-TARGETING
ON-TARGETplus Non-targeting Control siRNAs 50nmol
ABclonal Technology KO Validated SMARCB1/SNF5
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures allowing the transcriptional machinery to access its targets more effectively The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase This gene has been found to be a tumor suppressor and mutations in it have been associated with malignant rhabdoid tumors Alternatively spliced transcript variants have been found for this gene
ABclonal Technology KO Validated Rab12 MJFF-A-6E6
Rab12 a member of the RAS oncogene family is crucial for intracellular membrane trafficking This small GTPase protein mediates vesicle transport particularly from recycling endosomes to lysosomes playing a key role in autophagy and transferrin receptor degradation Rab12 cycles between inactive GDP-bound and active GTP-bound forms recruiting effectors for vesicle formation movement and fusion It is phosphorylated by LRRK2 which it also regulates Rab12 activates LRRK2 leading to increased phosphorylation of Rab10 aiding in lysosomal function Dysregulation of this pathway especially due to pathogenic LRRK2 mutations may contribute to neurodegenerative processes in Parkinson s disease
ABclonal Technology KD Validated DYNC1H1
Dyneins are a group of microtubule-activated ATPases that function as molecular motors They are divided into two subgroups of axonemal and cytoplasmic dyneins The cytoplasmic dyneins function in intracellular motility including retrograde axonal transport protein sorting organelle movement and spindle dynamics Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains This gene encodes a member of the cytoplasmic dynein heavy chain family
ABclonal Technology KD Validated Peroxiredoxin 6
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family This protein is a bifunctional enzyme with two distinct active sites It is involved in redox regulation of the cell it can reduce H(2)O(2) and short chain organic fatty acid and phospholipid hydroperoxides It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury
ABclonal Technology KO Validated HIF1AN/FIH-1
Enables several functions including 2-oxoglutarate-dependent dioxygenase activity NF-kappaB binding activity and transition metal ion binding activity Involved in several processes including negative regulation of Notch signaling pathway negative regulation of transcription from RNA polymerase II promoter in response to hypoxia and protein hydroxylation Located in cytosol nucleoplasm and perinuclear region of cytoplasm Colocalizes with nucleus
Sigma Aldrich Fine Chemicals Biosciences MISSION(R) esiRNA targeting human FBXO42 | 20UG
MISSION(R) esiRNA targeting human FBXO42 | 20UG
HORIZON DISCOVERY BIOSCIENCES LIMITED ACCLL HMN FGFR3 2261 SP 5NMOL
NC3365482 ACCLL HMN FGFR3 2261 SP 5NMOL
HORIZON DISCOVERY BIOSCIENCES LIMITED ON-TARGETPLUS HUM STK3 5NMOL
NC3866705 ON-TARGETPLUS HUM STK3 5NMOL
HORIZON DISCOVERY BIOSCIENCES LIMITED Accell Human TRIB3 (57761) siRNA
Accell Human TRIB3 (57761) siRNA - SMARTpool, 5 nmo