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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
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Tivanisiran (SYL1001) is a double-stranded small interfering RNA (siRNA) designed to silence transient receptor potential vanilloid 1 (TRPV1) mRNA for research into dry eye disease. It is supplied as an oligonucleotide reagent intended for laboratory and preclinical gene-silencing studies.
Silences TRPV1 mRNA to reduce ocular discomfort in dry eye models.
Double-stranded siRNA sequence for targeted gene knockdown.
High purity suitable for research applications (97.5%).
Characterized molecular weight approximately 12,068 Da.
Available in small pack sizes suitable for experiments (for example, 5 mg).
Sequence information provided to support assay design and verification.
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This gene encodes a member of the tripartite motif (TRIM) family The TRIM motif includes three zinc-binding domains a RING a B-box type 1 and a B-box type 2 and a coiled-coil region The encoded protein is part of the RoSSA ribonucleoprotein which includes a single polypeptide and one of four small RNA molecules The RoSSA particle localizes to both the cytoplasm and the nucleus RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined
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This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference The encoded protein is highly basic and contains a PAZ domain and a PIWI domain It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing Multiple transcript variants encoding different isoforms have been found for this gene
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