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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
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This gene belongs to the protein arginine methyltransferase (PRMT) family The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification A related pseudogene is located on chromosome 9
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Histone acetylation and deacetylation catalyzed by multisubunit complexes play a key role in the regulation of eukaryotic gene expression The protein encoded by this gene belongs to the histone deacetylase acuc apha family and is a component of the histone deacetylase complex It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation Together with metastasis-associated protein-2 it deacetylates p53 and modulates its effect on cell growth and apoptosis
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR TAP MRP ALD OABP GCN20 White) This protein is a member of the MRP subfamily which is involved in multi-drug resistance This family member plays a role in cellular detoxification as a pump for its substrate organic anions It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis Alternative splicing of this gene results in multiple transcript variants
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