Bioactive Small Molecules
Cayman Chemical ANTIBODY Ro 4929097 5mg
A potent, selective inhibitor of γ-secretase (IC50 = 4 nM) that blocks both Aβ40 and Notch processing (IC50s = 14 and 5 nM, respectively); orally active against cancer xenograft models, altering gene expression related to angiogenesis and cell differentiation
Medchemexpress LLC RXR antagonist 1 | 3010910-40-1 | 99.9% | 502.57 g·mol⁻¹ | C28H33F3N2O3 | 5 MG
RXR antagonist 1 is a small-molecule retinoid X receptor (RXR) antagonist used in biochemical and pharmacological research. It exhibits potent RXR-antagonistic activity (reported pA2 = 8.06) and is used in studies of RXR signaling and metabolic disease models, including type 2 diabetes.
- High chemical purity (99.94%).
- Molecular weight 502.57 g·mol⁻¹.
- Soluble in DMSO at 100 mg/mL; in vivo formulations reported.
- Available as small-scale powder and 10 mM DMSO solution.
- Recommended storage: powder -20°C; solutions -80°C.
Medchemexpress LLC Nor-Noha Monoacetate 10Mm 1Ml | HY-112885B-10MM 1ML/DMSO
Nor-Noha Monoacetate 10Mm 1Ml
Medchemexpress LLC Glurate (4-acetylbutyric acid) | 3128-06-1 | MFCD00004412 | 130.14 | 10 G
Glurate (4-acetylbutyric acid) is an acylating agent used in the development of antiviral compounds. It targets retroviruses such as herpes virus and HIV, and can also be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid.
- Acylating agent
- Used in development of antiviral compounds
- Targets retroviruses (herpes virus and HIV)
- Synthesis of acyclic nucleoside derivatives
- Synthesis of 5-hydroxyhexanoic acid
Medchemexpress LLC Dopamine Receptor D3 Antibody (YA1742) | 50 UL
Dopamine Receptor D3 Antibody (YA1742) is a rabbit-derived and non-conjugated IgG monoclonal antibody targeting Dopamine Receptor D3. It is reactive with human, mouse, and rat species, making it suitable for various research applications, particularly Western Blot (WB). The antibody is supplied as a liquid formulation containing rabbit IgG in 10mM phosphate-buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Targets dopamine receptor D3
- Reactive with human, mouse, and rat species
- Non-conjugated IgG monoclonal antibody
- Application in Western blot (WB) with a dilution ratio of 1:500-1:1000
- Predicted and observed band size of 44 kDa
- Stored at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
Cayman Chemical ANTIBODY TAK-779 1mg
An antagonist of CCR5, CCR2b, and CXCR3; inhibits CCR5 and CXCR3 (IC50s = 236 and 369 nM, respectively) and CCR5 and CCR2b (IC50s = 1.4 and 27 nM, respectively); inhibits the replication of clinical isolates of R5, but not X4, HIV-1 in human PBMCs (EC50s = 1.6-3.5 and >20,000 nM, respectively); inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in BALF, in a mouse model of asthma at 250 mg per animal per day; increases intestinal allograft survival in a rat model of small intestine transplantation at 10 mg/kg per day
Medchemexpress LLC Hydroxyethylthio vitamin K3 | 59147-84-1 | 248.30 g/mol | C13H12O3S | 25 MG
Hydroxyethylthio vitamin K3 is a research-grade small molecule reported to inhibit Cdc25 phosphatases and used in cell-cycle and tumor research. It is characterized by molecular formula C13H12O3S and molecular weight 248.30 g/mol, and is supplied in milligram-scale quantities for biochemical and cellular studies.
- Cdc25 phosphatase inhibitor with reported IC50 of 4.56 μM (Cdc25A) and 23.63 μM (Cdc25B).
- Small molecule with formula C13H12O3S and molecular weight 248.30 g/mol.
- Suitable for biochemical and cellular research applications.
- Provided in milligram-scale pack sizes with recommended storage at room temperature or cold solvent conditions.
- Solid appearance; handle according to standard laboratory safety practices.
Medchemexpress LLC Ly2389575 hydrochloride | 885104-09-6 | MFCD28133385 | 99.9% | 438.58 | C15H16BrCl3N4 | 25 MG
LY2389575 hydrochloride is a research-only small molecule that acts as a selective, non-competitive negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3). It is used to probe mGlu3 pharmacology and related pathways, including effects on Mrc1 levels and amyloid beta-related toxicity in preclinical studies.
- Selective non-competitive mGlu3 negative allosteric modulator with reported IC50 ≈ 190 nM.
- High reported purity suitable for biochemical and cellular assays.
- Available in small milligram quantities and solution formats for assay flexibility.
- Stable under recommended storage conditions for extended sample retention.
- Useful for studies of receptor modulation, signaling, and amyloid beta interactions.
Cayman Chemical EmtrIcItabIn S-oxIde 10mg
A potential impurity found in commercial emtricitabine preparations
Cayman Chemical ANTIBODY LH1307 5mg
An inhibitor of the PD-1/PD-L1 protein interaction (IC50 = 3 nM in an HTRF assay); increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays)
Medchemexpress LLC 1-Adamantylcarbinyl iodide | 51849-10-6 | 95.0% | 276.16 | 5 MG
1-Adamantylcarbinyl iodide is a drug intermediate used for the synthesis of various active compounds. It is for research use only.
- Drug intermediate
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Cayman Chemical ANTIBODY X-nuNAc 1mg
A chromogenic substrate for neuraminidases; the dark blue pigment 5,5’-dibromo-4-4’-dichloroindigo is released upon hydrolysis and can be used to quantify neuraminidase activity
Cayman Chemical ReparIxInL-LysIn salt 5mg
A non-competitive allosteric inhibitor of IL-8/CXCL8 activation of CXCR1 and CXCR2 chemokine receptors (IC50s = 1 and 100 nM, respectively); blocks IL-8-induced leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists; at 100 nM, depletes a cancer stem cell population in human breast cancer cell lines in vitro
Medchemexpress LLC Glucosamine (hydrochloride) | 66-84-2 | 215.63 | 25 MG
Glucosamine (hydrochloride) | 66-84-2 | 215.63 | 25 MG
Medchemexpress LLC (13E,15S)-15-hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid | 13345-51-2 | 1MG
(13E,15S)-15-hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid | 13345-51-2 | 1MG