Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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1
Tocris Bioscience™ Yoda 1
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Piezo1 channel activator
| Target | Other Calcium Channel Activators |
|---|---|
| CAS | 448947-81-7 |
| Purity | >99% |
| Chemical Name or Material | 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C13H8Cl2N4S2 |
| Formula Weight | 355.27 |
2
| CAS | 29767-20-2 |
|---|---|
| Molecular Formula | C32H32O13S |
3
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Invitrogen™ BODIPY™ 493/503 (4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-s-Indacene)
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Invitrogen™ BODIPY™ 493/503 (4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-s-Indacene)
BODIPY™ 493/503 can be used as a stain for neutral lipds, and as a tracer for oil and other nonpolar lipids.
Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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4
Tocris Bioscience™ DFHBI
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Mimic of GFP fluorophore for imaging RNA in living cells
| Target | Light-up Aptamers |
|---|---|
| CAS | 1241390-29-3 |
| Purity | >98% |
| Chemical Name or Material | (5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C12H10F2N2O2 |
| Formula Weight | 252.22 |
5
Tocris Bioscience™ AM 580
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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AM 580 synthesized to Ancillary Material Grade
6
Tocris Bioscience™ pCPA methyl ester hydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Tryptophan hydroxylase inhibitor
7
Tocris Bioscience™ Vancomycin HCl
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Antibiotic
8
Tocris Bioscience™ H-7 dihydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Protein kinase inhibitor
| CAS | 108930-17-2 |
|---|---|
| Solubility | Soluble to 20mM in DMSO |
| Chemical Name or Material | '±-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C14H17N3O2S.2HCl |
| Formula Weight | Observed MW: 364.29 |
| Assay Percent Range | >99% |
9
Tocris Bioscience™ AS 1842856
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective Foxo1 inhibitor; orally bioavailable
| CAS | 836620-48-5 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Molecular Formula | C18H22FN3O3 |
10
Tocris Bioscience™ S-Sulfo-L-cysteine sodium salt
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Group I agonist
| CAS | 7381-67-1 |
|---|---|
| Solubility | Soluble to 100 mM in water |
| Recommended Storage | Desiccate at -20°C |
| Molecular Formula | C3H6NO5S2Na |
| Formula Weight | Observed MW: 223.19 |
11
Tocris Bioscience™ A 412997 dihydrochloride
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Selective D4 agonist
| CAS | 1347744-96-0 |
|---|---|
| Chemical Name or Material | N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide |
| Recommended Storage | Desiccate at Room Temperature |
| Molecular Formula | C19H23N3O.2HCl |
| Formula Weight | Observed MW: 382.33 |
| Assay Percent Range | >98% |
12
Tocris Bioscience™ KY 02111
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
| CAS | 1118807-13-8 |
|---|---|
| Chemical Name or Material | N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C18H17ClN2O3S |
| Formula Weight | Observed MW: 376.86 |
| Assay Percent Range | >99% |
13
Tocris Bioscience™ A 83-01
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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A 83-01 synthesized to Ancillary Material Grade
14
Tocris Bioscience™ Tissue Clearing Pro
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Tissue clearing reagent kit
15
Tocris Bioscience™ SJF 1521
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective EGFR PROTAC™