Bioactive Small Molecules
Cayman Chemical racDesethyl OxybutynInhydr 5mg
An active metabolite of oxybutynin; binds to mAChRs in isolated rat bladder, submaxillary gland, heart, and colon (Kis = 5.38, 3.12, 16, and 5.59 nM, respectively); reduces micturition pressure in rats at 0.4 and 0.8 mg/kg
Medchemexpress LLC Pt(II) protoporphyrin IX | 98303-94-7 | 80.0% | 755.73 g/mol | C34H32N4O4Pt | 5 MG
Pt(II) protoporphyrin IX is a platinum(II)-metalated derivative of protoporphyrin IX used as a research reagent and chemical intermediate. It is a tetrapyrrolic heterocycle related to heme biosynthesis, with molecular formula C34H32N4O4 and molecular weight 755.73 g/mol. Typical purity is about 80.0% and the material is stored as a powder at low temperatures for long-term stability.
- Platinum(II)-metalated protoporphyrin core for mechanistic and spectroscopic studies.
- Suitable as a chemical intermediate and research reagent.
- Molecular formula C34H32N4O4 and molecular weight 755.73 g/mol for accurate dosing.
- Typical purity approximately 80.0% for experimental planning.
- Powder form with recommended storage at -20°C (powder) and colder for solutions to preserve stability.
Cayman Chemical ANTIBODY VU0152100 10mg
A positive allosteric modulator of M4 muscarinic acetylcholine receptors; potentiates ACh-induced calcium mobilization in CHO-K1 cells expressing the rat M4 receptor (EC50 = 380 nM); selective for M4 over M1, M2, M3 and M5 receptors, as well as a panel of 68 additional GPCRs, ion channels, transporters, and enzymes but does bind to the benzodiazepine binding site of the GABAA receptor at 10 µM; reduces cocaine-induced increases in locomotor activity and cocaine self-administration in mice at 1 mg/kg
Cayman Chemical ANTIBODY MXS 5mg
A fluorescent probe for hypochlorous acid; selectively fluoresces in the presence of OCl- over O2, H2O2, NO, NO2-, NO3-, O2-, ONOO-, and •OH at 10 µM; has been used to monitor real-time mitochondrial HOCl levels in living cells; excitation/emission maxima = 530/654 nm, respectively
Cayman Chemical ANTIBODY BItertnol 500mg
A triazole fungicide; active against a variety of fungi, including isolates of V. inaequalis (MICs = 0.6 and 1 UG/ml) but repeated use leads to resistance (MICs = 9.8-13 UG/ml for resistant isolates); inhibits CYP3A4 (IC50 = 2.74 µM) and DHT-induced androgenic activity (IC50 = 79.85 µM); increases operant responding in rats (10-300 mg/kg, i.p.)
Medchemexpress LLC Glimepiride impurity 1 | 119018-30-3 | MFCD08282469 | 5mg
Glimepiride impurity 1 is an impurity of Glimepiride (HY-B0104)
AdipoGen PBFI-AM (1 mg)
Chemical. CAS: 124549-23-1. Formula: C58H62N2O24. MW: 1171.11. PBFI AM is a cell-permeable, potassium-sensitive fluorophore used to measure potassium changes in cells and intracellular compartments. As PBFI AM enters cells, it is hydrolyzed by intracellular esterases to produce PBFI. The affinity of PBFI for potassium is sodium-dependent (Kd=44 and 5.1mM with or without sodium, respectively). Spectral data: lambdaEx=370nm; lambdaEm=540nm in methanol.
Medchemexpress LLC N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzamide | 639858-32-5 | 99.6% | 100 MG
BMS-605541 is a selective, orally active VEGFR-2 kinase inhibitor used in cancer research. It demonstrates potent inhibition of VEGFR-2 and measurable activity against VEGFR-1 and PDGFR-β.
- Selective VEGFR-2 (Flk-1) inhibition with low nanomolar potency.
- Demonstrated activity against VEGFR-1 and PDGFR-β for pathway studies.
- High purity (99.6%) suitable for in vitro and cellular research.
- Available in multiple solid pack sizes and as a 10 mM solution in DMSO.
- Commonly used in cancer research and VEGF/PDGF signaling studies.
Medchemexpress LLC Zaprinast | 37762-06-4 | 99.88% | 50 MG
Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5) that significantly increases cGMP levels in myocytes. It is also a G protein-coupled receptor 35 (GPR35) agonist, activating rat GPR35 strongly and human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.
- Selective inhibitor of cGMP-selective Phosphodiesterase (PDE5).
- Increases cGMP levels in myocytes.
- G protein-coupled receptor 35 (GPR35) agonist.
- Reduces vessel remodeling through antiproliferative and proapoptotic effects.
- Enhances spatial memory and diminishes exploratory activity in mice.
Apexbio Technology LLC Alvelestat 848141-11-7 10mM (in 1mL DMSO)
Alvelestat (CAS 848141-11-7) is an orally bioavailable reversible inhibitor of neutrophil elastase (NE) It demonstrates high affinity for human NE exhibiting a Ki of 9 4 nM and over 600-fold selectivity compared to other serine proteases In whole blood cell-based and degranulation assays alvelestat shows pIC50 values of 7 36 7 32 and 7 3 respectively Preclinical studies indicate that alvelestat reduces NE-induced markers of lung injury such as hemoglobin and hydroxyproline levels and attenuates neutrophilic inflammation in models of acute lung injury as well as smoke-induced airway inflammation and emphysema These properties support its use in research on neutrophil-driven pulmonary diseases
Medchemexpress LLC Animal-free IL-1 beta protein, mouse (His) | 10UG
Animal-Free IL-1 beta Protein, Mouse (His) is a recombinant mouse interleukin-1 beta (IL-1β) provided in an animal-free production format with a C-terminal His tag. It is supplied in small vial sizes suitable for in vitro research and biochemical characterization; molecular weight is approximately 17-19 kDa by SDS-PAGE.
- Recombinant mouse IL-1 beta with C-terminal His tag.
- Animal-free production to reduce animal-derived contaminants.
- Available in 10 μg and 50 μg sizes for small-scale experiments.
- Approximate molecular weight 17-19 kDa (reducing conditions).
- Datasheet and safety data sheet available for handling and storage information.
eMolecules 1269181-69-2 | Medchem Express | Nicodicosapent | 2mg | 446268806 | HY-17640 | 449.639 | C28H39N3O2
Ambeed | 18-((25-Dioxopyrrolidin-1-yl)oxy)-18-oxooctadecanoic acid | 100mg | 600838450 | A357864 | 146004-84-4 | 411.539 | C22H37NO6
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Cayman Chemical IndolIcIdIntrIfluoroacetAT 5mg
An antimicrobial peptide; active against MDR-EAEC (MICs = 32 µM for all); active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 µM, respectively); reduces viral replication of HIV-1 in MT-2 cells from 67-100 UG/ml; increases survival of MDR-EAEC-infected G. mellonella larvae
Cayman Chemical ANTIBODY ML-396 25mg
A positive allosteric modulator of group III mGluRs (EC50s = 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays); potentiates LSP4-2022-induced reductions in fEPSP slopes in mouse hippocampal slices; restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome at 30 mg/kg
Medchemexpress LLC XAV-939 | 284028-89-3 | MFCD08272370 | C14H11F3N2OS | 1 G
XAV-939 is a potent and selective Tankyrase (TNKS) inhibitor that targets TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. It functions by inducing β-catenin degradation through the stabilization of Axin. This compound is valuable for research into conditions associated with activated Wnt signaling, including various cancers, fibrotic diseases, and disorders characterized by low bone formation. It also enhances the osteoblastic differentiation of hMSCs.
- Potent and selective Tankyrase (TNKS) inhibitor
- Induces β-catenin degradation
- Stabilizes Axin
- Enhances osteoblastic differentiation of hMSCs
- Useful for research of Wnt signaling-related conditions
- Relevant for studies on cancer, fibrotic diseases, and low bone formation conditions