Bioactive Small Molecules
TARGETMOL CHEMICALS INC CPI-1205 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 0.002 uM EC50 0.032 uM) . purity: 99%
Cayman Chemical BB-Cl-AmIdIntrIfluoroaceta 5mg
A pan PAD inhibitor; irreversibly inhibits PAD1-4 (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1, respectively); inhibits PMA-induced NET formation in mouse bone marrow-derived neutrophils at 20 and 200 µM; inhibits HSV-1-induced IFN-β production in mouse BMDMs at 1 µM; reduces diABZI STING agonist-1-induced BMDM IFN-β and TNF-α production in wild-type, Pad2-/-, and Pad4-/- mice at 10 mg/kg; increases survival, as well as reduces splenomegaly, myocarditis, and cardiac fibrosis in a Trex1D18N/D18N mouse model of AGS at 20 mg/kg per day
Abcam MM1-43, membrane selective dye, 5MG
MW 611.5 Da, Purity >99%. Membrane selective dye. Reversibly binds to the outer leaflet of surface membranes without permeating. Internalizes into vesicles during endocytosis. Dissociates from the membrane during exocytosis. Also available in simple stock solutions (ab146741) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Bhpi | 56632-39-4 | 98.0% | 10 MG
BHPI is a nuclear receptor ERα inhibitor that activates PLCγ and UPR. It exhibits potent antitumor activity against various cancers, including breast, endometrial, and ovarian cancers.
- Inhibits proliferation of ERα-positive breast, endometrial, and ovarian cancer cells.
- Inhibits cell proliferation in two-dimensional adherent cultures of T47D, ERαY537S-4, and ERαD538G-1 cells.
- Demonstrates in vivo tumor growth inhibition and regression in mouse xenograft models using MCF-7 tumors.
Medchemexpress LLC PND-1186 (VS-4718) | 1061353-68-1 | 99.9% | 501.50 | 100 MG
PND-1186 (VS-4718) is a potent, highly-specific, and reversible inhibitor of FAK with an IC50 of 1.5 nM. It selectively promotes tumor cell apoptosis.
- Potent, highly-specific, and reversible FAK inhibitor.
- Selectively promotes tumor cell apoptosis.
- Inhibits FAK Tyr-397 phosphorylation in breast carcinoma cells.
- Reduces tumor growth by inducing apoptosis.
Medchemexpress LLC Methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside | 6082-04-8 | MFCD00056076 | >98.0% | 235.23 g/mol | C9H17NO6 | 1 G
Methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside is a small-molecule biochemical reagent primarily used in glycobiology and synthetic organic chemistry. It functions as an N-acetylglucosaminide building block and analytical standard for research workflows, supplied as a purified solid suitable for laboratory handling and storage.
- High purity (>98%) reagent suitable for analytical and synthetic applications.
- Solid form with defined molecular weight for accurate dosing.
- Useful as an N-acetylglucosaminide building block in glycochemistry.
- Compatible with common organic solvents and standard storage conditions.
- Available in multiple laboratory-scale package sizes for experimental flexibility.
eMolecules 5361-15-9 | Medchem Express | GMQ | 10mg | 783660358 | HY-107757 | MFCD00035249 | 237.69 | C10H12ClN5
Medchem Express | GMQ | 10mg | 783660358 | HY-107757 | 5361-15-9 | MFCD00035249 | 237.690 | C10H12ClN5
Medchemexpress LLC Homatropine methylbromide | 80-49-9 | 98.0% | 50 MG
Homatropine methylbromide is a muscarinic AChR antagonist that inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 values of 162.5 nM and 170.3 nM, respectively. It is intended for research use only and not for sale to patients.
- Muscarinic AChR antagonist
- Inhibits endothelial and smooth muscle muscarinic receptors
- Available in solid and solution forms
Medchemexpress LLC HY-135815A 10mg Medchemexpress, Mobocertinib (succinate) CAS:2389149-74-8 Purity:>98%
Medchemexpress, HY-135815A 10mg Mobocertinib (succinate) CAS:2389149-74-8 Mobocertinib succinate (TAK-788 succinate) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC ErSO-DFP | 2768139-76-8 | 99.6% | C20H17F5N2O2 | 10MG
ErSO-DFP is a small-molecule anticipatory unfolded protein response (a-UPR) activator with enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells. It demonstrates antitumor activity in animal models and can cross the blood-brain barrier, supporting its use in both in vitro and in vivo research into ERα+ cancer biology and UPR mechanisms.
- Activates the anticipatory unfolded protein response (a-UPR).
- Shows enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells.
- Demonstrates antitumor activity in mouse models.
- Capable of crossing the blood-brain barrier.
- Reported high purity (99.6%), suitable for research applications.
- Available in multiple small pack sizes for laboratory use.
Medchemexpress LLC Glpg1837 (abbv-974) | 1654725-02-6 | 99.9% | 348.42 | 10 UG
GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. It increases the conductivity of the G551D CFTR channel with an obtained potency of 181 nM.
- Potent and reversible CFTR potentiator.
- EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
- Increases the conductivity of the G551D CFTR channel with an obtained potency of 181 nM.
Medchemexpress LLC 9H-Purine-9-propanamine, 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-, hydrochlo | 2095432-24-7 | 99.25% | 548.83 | 1 ML
9H-Purine-9-propanamine, 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-, hydrochlo | 2095432-24-7 | 99.25% | 548.83 | 1 ML
Cayman Chemical ANTIBODY DUPA 5mg
An inhibitor of PSMA (IC50 = 47 nM for the glutamate carboxypeptidase activity); has been used as a ligand to target radiolabels, cytotoxic agents, and antibody-drug conjugates to cancer cells
Cayman Chemical TaurocholIc AcId 3sulfATs 5mg
A metabolite of taurocholic acid; plasma levels are elevated in wild-type and Sort1 knockout mice at 6 hours post-BDL and are further elevated in Sort1 knockout mice at 24 hours post-BDL