Bioactive Small Molecules
Cayman Chemical ANTIBODY OF-02 1mg
An ionizable cationic amino lipid; has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA; LNPs containing OF-02 localize to the liver after intravenous administration in mice; intravenous administration of LNPs containing OF-02 and encapsulating human EPO mRNA increases serum EPO levels in mice
TARGETMOL CHEMICALS INC NEGLETEIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-(alpha) iNOS and IL-1(beta). 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential and it (50 uM 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. purity: 99%
Cayman Chemical ANTIBODY ICA 069673 50mg
A Kv7 channel activator; selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner; has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM); increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively)
Medchemexpress LLC Elimusertib hydrochloride | 99.9% | 411.89 | 100 MG
Elimusertib hydrochloride (BAY 1895344) is a potent, orally active, and selective ATR inhibitor with an IC50 of 7 nM. It demonstrates anti-tumor activity and can be used for research on solid tumors and lymphomas.
- Potent, orally active, and selective ATR inhibitor
- Demonstrates anti-tumor activity
- Applicable for research on solid tumors and lymphomas
- Inhibits proliferation of human tumor cell lines
- Suppresses hydroxyurea-induced H2AX phosphorylation
- Shows good selectivity against related kinases
- Potent antiproliferative activity against various cancer cell lines in vitro
- Potent anti-tumor efficacy in monotherapy in xenograft models
- Causes complete tumor remission in mantle cell lymphoma models
- Synergistic antitumor activity with Carboplatin in relevant models
- Exhibits moderate oral bioavailability
Cayman Chemical ANTIBODY N106 5mg
An activator of SERCA2A SUMOylation; activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes from 0.1-1 µM; increases contractility in the same cells; increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure at 10 mg/kg
Cayman Chemical ANTIBODY Velaresol 5mg
An Hb-O2 stabilizer; increases erythrocyte deformability in isolated human blood from a patient with sickle cell disease at 1.5 mM; inhibits deoxygenation-induced decreases in erythrocyte deformability in isolated human blood from a patient with sickle cell disease at 3 or 5 mM; decreases oxygen tension and increases oxygen saturation of isolated human sickle erythrocytes at 5 mM
Cayman Chemical -LY426965hydrochlorIde 5mg
A racemic mixture of (S)-(+)-LY426965 and (R)-(–)-LY426965
Medchemexpress LLC Shogaol | 555-66-8 | 99.84% | 276.37 | 1 ML
Shogaol is an active compound derived from Ginger (Zingiber officinale Rosc) and demonstrates a range of biological activities, including anticancer, anti-inflammatory, and antioxidant effects.
- Exhibits anticancer activity across various cell lines.
- Inhibits LPS-induced nitric oxide production, demonstrating anti-inflammatory action.
- Upregulates antioxidant defense systems in cells and in vivo.
- Protects against liver damage and lipid peroxidation.
- Restores hepatic antioxidant enzymes.
- Stimulates phosphorylation of mitogen-activated protein kinases (MAPKs).
- Offers neuroprotection against beta-Amyloid insult.
- Modulates human TRPV1 and rat TRPA1 ion channels.
Cayman Chemical ANTIBODY HyperIcIn 10mg
An anthroquinone derivative found in St. John’s wort; inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA, and L-glutamate; broad spectrum phototoxic effects (IC50 = 140-1570 nM) in cancer cells; induces apoptotic signaling and formation of ROS; in vitro antiviral activity against HIV, influenza, hepatitis C, murine cytolomegalovirus, and herpes viruses
Medchemexpress LLC Trans-R-138727 | 239466-74-1 | 99.0% | 349.42 g/mol | C18H20FNO3S | 5MG
trans-R-138727 is the trans stereoisomer of R-138727, the thiol-containing active metabolite of prasugrel. Supplied as a solid research reagent, it is used to study P2Y12 receptor-mediated platelet inhibition, pharmacology, and related biochemical assays.
- Trans stereoisomer of R-138727 and active metabolite of prasugrel.
- Irreversible P2Y12 receptor inhibitor used in platelet function research.
- High purity (≈99%) solid powder suitable for analytical work.
- Chemical formula C18H20FNO3S; molecular weight 349.4 g/mol.
- Recommended storage: powder -20°C; in solvent -80°C for 6 months or -20°C for 1 month.
- Available in small research sizes, including 5 mg vials.
Cayman Chemical ANTIBODY CAY10614 10mg
An antagonist of lipid A activation of TLR4 (IC50 =1.68 μM), in a cell-based assay; significantly improves survival of mice given intraperitoneal LPS
Medchemexpress LLC AZ'9567 | 3056570-19-2 | 99.2% | 447.44 | 5 MG
AZ9567 is identified as a potent inhibitor of MAT2A. It has demonstrated antiproliferative activity against MTAP KO HCT116 cells, with a pIC50 of 8.9.
- Potent MAT2A inhibitor.
- Exhibits antiproliferative activity against MTAP KO HCT116 cells.
- Available in solid form (white to off-white appearance).
- High purity of 99.21%.
Medchemexpress LLC Gyrophoric acid | 548-89-0 | 5 MG
Gyrophoric acid is an ultraviolet filter found in lichen populations and exhibits DPPH radical scavenging activity.
- Exhibits DPPH radical scavenging activity with an IC50 value of 105.75 μg/ml.
- Shows antiproliferative activity against human HaCaT cells with an IC50 of 1.7 μM.
- Inhibits LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with an IC50 of > 60 μM.
- Decreases mitochondrial membrane potential in ovarian cancer cells A2780 at 200 μM.
- Inhibits cell growth and affects expression of Bcl-2, Bax, and Hsp70 proteins in A375 melanoma cancer cells.
- Induces ROS production, apoptosis, DNA damage, and alters stress/survival protein activity in HeLa cells.
Medchemexpress LLC SFRP2 Human HEK293 50ug | 50ug
SFRP2 Protein is a soluble crimson-associated protein that promotes tumor development by activating the Wnt/ -catenin signaling pathway The methylation of SFRP2 Protein DNA is associated with tumor development SFRP2 Protein Human (HEK293 His solution) is the recombinant human-derived SFRP2 protein expressed by HEK293 with C-His labeled tag
Cayman Chemical ANTIBODY Mps1-IN-1 500ug
A selective inhibitor of Mps1 kinase (IC50 = 367 nM); disrupts the recruitment of Mad2 to kinetochores and increases the frequency of multipolar mitosis in U2OS cells