Bioactive Small Molecules
Abcam Camostat mesylate, TMPRSS2 inhibitor, 50MG
MW 494.52 g/mol, Purity >98%. Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC₅₀ = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis. Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sildenafil citrate, phosphodiesterase 5 (PDE5) inhibitor, 10MG
MW 666.7 Da, Purity >99%. Potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ = 4 nM). Various pharmacological effects in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WP1066, JAK/STAT3 inhibitor, 5MG
MW 356.2 Da, Purity >97%. JAK/STAT3 inhibitor (IC₅₀ = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Thiolutin, antibiotic agent, 5MG
MW 228.3 Da, Purity >98%. Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC₅₀ = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB-366791, TRPV1 antagonist, 5MG
MW 287.74 Da, Purity >99%. Potent, selective TRPV1 antagonist. Rapidly and reversibley inhibits capsaicin, acid, or heat mediated activation of human TRPV1 (IC₅₀ values are 3 and 6 nM for capsaisin and heat respectively). Active in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC FIN56 5mg 1083162-61-1
FIN56 is a specific inducer of ferroptosis . *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC IACS-010759 (IACS-10759) 5mg 1570496-34-2
IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC LY3214996 2mg 1951483-29-6
LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Eganelisib (IPI-549) 5mg 1693758-51-8
Eganelisib (IPI-549) is a potent inhibitor of PI3K-? with >100-fold selectivity over other lipid and protein kinases. The biochemical IC50 for PI3K-? is 16 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC PF-06409577 10mg 1467057-23-3
PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for ?1?1?1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 ?M) and was not an inhibitor (IC50 > 100 ?M) of the microsomal activities of major human cytochrome P450 isoforms. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Rosmarinic acid 25mg 20283-92-5 Rosemary acid
Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-? activity in NF-?B activation signaling. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Metoprolol 25mg 51384-51-1
Metoprolol is a cardioselective ?1-adrenergic blocking agent with log Kd values of ?7.26¿0.07, ?6.89¿0.09, ?5.16¿0.12 for ?1, ?2, and ?3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Salmeterol 5mg 89365-50-4 Astmerole, GR-33343X, SN408D
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT ?2AR and shows very high selectivity for the WT ?2AR(?1Ki/?2Ki ratio of approximately 1500). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Astaxanthin 5mg 472-61-7 -Carotene-4,4'-dione, Trans-Astaxanthin
Astaxanthin (?-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPAR? and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam CAY10621 (SKI 5C), SPHK 1 inhibitor, 25MG
MW 435.6 Da, Purity >98%. Selective SPHK 1 inhibitor (IC₅₀ = 3.3 μM). Induces cell cycle arrest in sub-G1 phase. Shows antiproliferative effects. Inhibits ERK1/2 and AKT signaling. Shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement