Bioactive Small Molecules
Cayman Chemical ANTIBODY 15 S-HETE 25ug
An active metabolite of arachidonic acid; inhibits proliferation of HT-29 colorectal and PC3 prostate cancer cells (IC50s = 40 and 30 µM, respectively); increases KLF10 and decreases Bcl-2 protein levels in HT-29 cells at 40 µM; increases HMG-CoA reductase levels in HDMVECs at 0.1 µM; increases Rac1 protein levels and induces farnesylation of Rac1 in HDMVECs at 0.1 µM
Cayman Chemical ANTIBODY18-HEPE 100ug
A non-enzymatic oxidation product of EPA; increased in the plasma and heart, as well as in the supernatant of cultured peritoneal macrophages isolated from fat-1 transgenic mice; reduces increases in cardiac fibrosis and the expression of Nppa, Col1a1, Tgfb1, Cx3cl1, and Adgre1 induced by transverse aortic constriction in a mouse model of cardiac hypertrophy at 1 and 5 UG
Cayman Chemical ANTIBODY Go 6976 500ug
A PKCα and PKCβ1 inhibitor with IC50 values of 2.3 and 6.2 nM, respectively; also inhibits the checkpoint kinases Chk1/2 and abrogates DNA damage-induced cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells
Cayman Chemical ANTIBODY SesamolIn 1mg
A lignin with diverse biological activities; reduces lipid peroxidation in rat liver and kidneys in vivo; reduces epididymal white adipose tissue weight and serum triacylglcerol, free fatty acid, phospholipid, and cholesterol concentrations in rats; inhibits growth of Molt-4B human lymphoid leukemia cells via induction of apoptosis in a dose-dependent manner; reduces hypoxia-induced LDH release and dichlorofluorescin-sensitive ROS production in BV-2 microglia grown under hypoxic conditions
Cayman Chemical IndIrubIn-3-monxIme 1mg
A potent inhibitor of GSK3β (IC50 = 22 nM), preventing tau phosphorylation both in vitro and in vivo
Cayman Chemical ANTIBODY PD 0325901 10mg
A potent MEK inhibitor that suppresses phosphorylation of ERK in murine colon 26 tumors with an IC50 value of 0.33 nM; suppression of ERK activation with 1 µM PD 0325901 combined with 3 µM CHIR99021 (a glycogen synthase kinase-3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages
Cayman Chemical ANTIBODY PD 0325901 5mg
A potent MEK inhibitor that suppresses phosphorylation of ERK in murine colon 26 tumors with an IC50 value of 0.33 nM; suppression of ERK activation with 1 µM PD 0325901 combined with 3 µM CHIR99021 (a glycogen synthase kinase-3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages
Cayman Chemical ANTIBODY BIndarIt 25mg
An inhibitor of MCP production; selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8; inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC50s = 172 and 403 µM, respectively); delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis at 50 mg/kg; prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg; a noncompetitive inhibitor of MCT4 (Ki = 30.2 µM) that is selective for MCT4 over MCT1
Cayman Chemical nacardIc AcId 5mg
An alkyl salicylic acid isolated from cashew shells; inhibits the HAT activity of p300 and PCAF (IC50 = 8.5 and 5 µM, respectively); suppresses NF-κB activation, inhibits IκBα phosphorylation, and prohibits p65 nuclear translocation
Cayman Chemical NF449sodIum salt 5mg
An analog of suramin that selectively inhibits P2X1 receptors (pIC50 = 6.3); selectively antagonizes the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to certain GPCRs
Cayman Chemical ANTIBODY GlycIteIn 25mg
An O-methylated isoflavone with weak estrogenic activity (IC50 = 3.94 μM) that has been used in research related phytoestrogen therapeutic activity applied to bone formation, cardiovascular disease, estrogen-dependent cancer, and Alzheimer’s disease
Cayman Chemical ANTIBODY 11 S-HEDE 100ug
11(S)-HEDE is isolated by the chromatographic resolution of (±)11-HEDE. There are no reports of biological activity associated with 11(S)-HEDE in the literature.
Cayman Chemical ANTIBODY 9-OxoDE 50ug
9-OxoODE results from oxidation of the allylic hydroxyl of either 9(S)- or 9(R)-HODE. Rabbit reticulocyte plasma and mitochondrial membranes contain both 9- and 13-oxoODEs, representing about 2% of the total linoleate residues in the membranes. Most of these oxidized linoleate residues are esterified to membrane lipids.{2262,2326,2261}
Cayman Chemical ANTIBODY OlIvetol 10mg
An analytical reference standard categorized as a resorcinol; has been found in Cannabis vape cartridges; intended for research and forensic applications
Cayman Chemical ANTIBODY15-HETE 50ug
(±)15-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)15-HETE is similar to that of its constituent enantiomers (Item Nos. 34720 and 34710).