Bioactive Small Molecules
Selleck Chemical LLC Sofituzumab vedotin-D4036-1MG
Sofituzumab Vedotin (DMUC5754A RG-7458) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody (mAb) and a potent anti-mitotic agent monomethyl auristatin E (MMAE) linked through a protease-labile linker DMUC5754A binds to the MUC16 extracellular domain with high affinity
Selleck Chemical LLC Rimonabant hydrochloride E4858-5MG
Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective antagonist of the central cannabinoid receptor (CB1) with a Ki of 1 8 nM It is an anorectic anti-obesity drug with potential to treat obesity and cardiovascular risk factors
Cayman Chemical ANTIBODY PerIplocIn 10mg
A cardiac glycoside with anticancer activity; increases viability and proliferation of CMECs at 2-50 µM; improves left ventricular structure and function in a rat model of chronic heart failure; inhibits cell proliferation in nine lung cancer cell lines (IC50s = 0.12-53 µM); induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway; reduces tumor growth in an HCC mouse xenograft model at 5 and 20 mg/kg; inhibits tumor growth in an A549 lung cancer mouse xenograft model at 50 and 100 UG
Cayman Chemical ANTIBODY NylIdrIn 50mg
An agonist of β-ARs and antagonist of NR1A/2B subunit-containing NMDA receptors; binds to β-adrenergic receptors (Kd = 0.37 µM) and activates adenylate cyclase (Ka = 1.3 µM); selective for NR1A/2B over NR1A/2A and NR1A/2C subunit-containing NMDA receptors (IC50s = 0.18, 32, and 42 µM, respectively); inhibits NMDA-induced responses in primary rat cortical neurons (IC50 = 0.22 µM); decreases blood pressure and increases heart rate in SHRs (MED = 0.5 mg/kg); inhibits influenza hemagglutinin 2-mediated membrane fusion in Vero E6 cells at 20 and 100 µM; inhibits infection of MDCK cells by H1N1 and H3N2 influenza isolates in vitro (EC50s = 7.2 and 12.1 µM, respectively) and prevents infection in a mouse model of mouse-adapted H1N1 infection
Cayman Chemical 4-acetoxy McPTfumarate 5mg
An analytical reference standard categorized as a tryptamine; intended for research and forensic applications
Selleck Chemical LLC Pardoprunox S0104-5MG
Pardoprunox hydrochloride (DU-126891 SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8 0 and a partial agonist in the induction of [35S]GTP S binding with pEC50 of 9 2 and a serotonin 5-HT1A receptor agonist with pEC50 of 6 3 respectively
Cayman Chemical ANTIBODY NI-42 25mg
An inhibitor of the BRPF1 bromodomain (IC50 = 7.9 nM); selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively); inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 AML cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 µM, respectively) and a variety of non-AML cells (GI50s = 1-10 µM); also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 µM, respectively)
Cayman Chemical 3-hydroxy DecnoIc AcId 5mg
A hydroxy fatty acid; predominant monomer in PHA polymers produced by P. putida CA-3; present in LPS from the H. pylori strain SS1 and in the lipid A component of clinical isolates of P. aeruginosa isolated from patients with cystic fibrosis; inhibits mitotic progression of O. virens pollens via impairment of plasma membrane function; induces a reversible shape change of the membrane crenation in human erythrocytes