Bioactive Small Molecules
Cayman Chemical ANTIBODY8-HDHA 50ug
(±)8-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
Cayman Chemical ANTIBODY FOG9 100ug
FOG9 is formed through the conjugation of 5-oxoETE with glutathione in a 1,6 Michael addition at C-9. The biological activity of FOG9 has not been determined. However, FOG7, a 1,4-adduct formed within murine peritoneal macrophages, was found to be highly potent in stimulating eosinophil and neutrophil chemotaxis.{8518} FOG7 was also capable of initiating actin polymerization without elevating intracellular free calcium ion concentration within either the eosinophil neutrophils or PMNL.
Cayman Chemical ANTIBODY9-HETE 250ug
A monohydroxy fatty acid; formed by lipid peroxidation of arachidonic acid, as well as by rat liver microsomal CYP; plasma levels are elevated in patients with angiographically defined coronary artery disease
Cayman Chemical ANTIBODY CBDB 5mg
An analytical reference standard categorized as a phytocannabinoid; considered an impurity in commercial preparations of cannabidiol; intended for research and forensic applications
Cayman Chemical ANTIBODY12-HETE 50ug
A racemic mixture of arachidonic acid metabolites; induces aggregation of isolated human neutrophils at 1 µM; production of (±)12-HETE by platelets isolated from spontaneously hypertensive rats is increased compared with platelets isolated from normotensive rats
Cayman Chemical ANTIBODY16-HDHA 25ug
(±)16-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
Cayman Chemical ArachIdonIc AcId-d8 5mg
An internal standard for the quantification of arachidonic acid by GC- or LC-MS
Cayman Chemical ANTIBODY 13-OxoDE 25ug
13-oxoODE is produced from 13-HODE by a NAD+-dependent dehydrogenase present in rat colonic mucosa.{184} 13-OxoODE stimulates cell proliferation when instilled intrarectally in rats.{2210} 13-OxoODE has also been detected in preparations of rabbit reticulocyte plasma and mitochondrial membranes, mostly esterified to phospholipids. Production of 13-oxoODE is putatively linked to the maturation of reticulocytes to erythrocytes through the activity of 15-LO.{2261,2262}
Cayman Chemical ANTIBODY 11 S-HEDE 50ug
11(S)-HEDE is isolated by the chromatographic resolution of (±)11-HEDE. There are no reports of biological activity associated with 11(S)-HEDE in the literature.
Cayman Chemical ANTIBODY 11 S-HEPE 50ug
11(S)-HEPE is a monohydroxy fatty acid derived from EPA, theoretically by the action of COX. Although its arachidonate derived congener 11(S)-HETE has been isolated from cultured neutrophils, it is not known if similar incubations with EPA can produce 11(S)-HEPE.{1088}
Cayman Chemical ANTIBODY YM-155 10mg
A small molecule that suppresses transactivation of survivin through direct binding to its promoter; induces apoptosis in p53-deficient cancer cells in vitro at 10 nM with little effect on expression levels of other IAP- or Bcl-2-related proteins
Cayman Chemical Psorala corylfola Bavachn 5mg
A phytoestrogen that activates ERα and ERβ (EC50s = 320 and 680 nM, respectively); stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats
Cayman Chemical ANTIBODY SB 225002 5mg
A selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 (IC50 = 22 nM)
Cayman Chemical MK-2206hydrochlorIde 5mg
An orally active, allosteric Akt inhibitor (IC50s = 5, 12, and 65 nM for Akt1, 2, and 3, respectively); inhibits cell proliferation of human cancer cell lines synergistically in combination with other topoisomerase inhibitors, antimetabolites, antimicrotubule agents, DNA cross-linkers or growth factor inhibitors