Bioactive Small Molecules
Cayman Chemical Thymopentn 5mg
A pentapeptide fragment of thymopoietin; induces prothymocyte differentiation in isolated mouse splenocytes at 0.018-18 µM; increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human PBLs at 1 UG/ml; reduces the number of splenic autologous rosette-forming cells in athymic mice at 0.02-10 mg/kg; adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model
Medchemexpress LLC Fluo-4 AM | 273221-67-3 | MFCD18837018 | 97.7% | 1096.94 g·mol⁻¹ | C51H50F2N2O23 | 5 MG
Fluo-4 AM is a cell-permeable acetoxymethyl (AM) ester calcium indicator that is hydrolyzed by intracellular esterases to release fluorescent Fluo-4. It enables measurement of intracellular Ca2+ dynamics in live cells, and is suitable for fluorescence microscopy, plate readers, flow cytometry, and high-throughput screening (Ex 485 nm / Em 526 nm).
- Cell-permeable AM ester for live-cell calcium imaging.
- Bright green fluorescence upon Ca2+ binding (Ex 485 nm, Em 526 nm).
- Compatible with microscopy, plate readers, and flow cytometry.
- Cleaved by intracellular esterases to yield active fluorescent dye.
- Available in multiple package sizes for varied experimental scales.
Carbosynth LLC. Cisapride (powder), 50 mg
This item has a minimum order quantity of 2 per supplier requirements
Cisapride chemical reference substance
Cayman Chemical CUMYL-CB-MeGACLOn 5mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
TARGETMOL CHEMICALS INC PX-12 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1) stimulates apoptosis down-regulates HIF-1(alpha) and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal gastric and lung cancers PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival. purity: 99%
Cayman Chemical ANTIBODY EMD 638683 5mg
An inhibitor of SGK1; inhibits SGK1 by 85% at 1 µM; >27-fold selective for SGK1 over a panel of 11 kinases, but does inhibit SGK2, SGK3, PRK2, and MSK1 by >50% at 1 µM; inhibits phosphorylation of the SGK1 target NDRG1 in HeLa cells (IC50 = 3.35 µM); increases radiation-induced apoptosis of Caco-2 colon carcinoma cells at 50 µM; dietary administration reduces the number of tumors in a mouse model of chemical carcinogenesis; prevents fructose and saline consumption-induced increases in systolic blood pressure in mice; decreases body weight, fasting blood glucose and HbA1c levels, and food intake in db/db diabetic mice; reduces angiotensin II-induced collagen deposition and cardiac fibrosis in mice
Cayman Chemical AT2 AgonIst C21 10mg
An AT2 receptor agonist; selectively binds to the AT2 receptor over the AT1 receptor (Kis = 0.4 and >10 µM, respectively); induces neurite outgrowth in NG 108-15 cells at 0.1 µM; reduces mean arterial blood pressure in anaesthetized SHRs at 0.05 mg/kg; reduces right ventricle hypertrophy and fibrosis, as well as lung interstitial and perivascular fibrosis, in an MCT-induced rat model of pulmonary hypertension at 0.3 mg/kg; increases survival and reduces neurological deficits in an MCAO-induced mouse model of cerebral ischemia
Cayman Chemical AdenylosuccInIc AcId 5mg
A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD
Cayman Chemical ANTIBODY BPR1J-097 50mg
An FLT3 inhibitor (IC50 = 11 nM); selective for FLT3 over FLT1, KDR, Aurora A, and Aurora B kinases (IC50s = 211, 129, 340, and 876 nM, respectively); inhibits FLT3 activity and phosphorylation of STAT5 in MV4-11 AML cells containing the FLT3 activating mutant FLT3-ITD (IC50s = 10 and 1 nM, respectively); inhibits the growth of FLT3-dependent MOLM-13 and MV4-11 AML cells (GI50s = 21 and 46 nM, respectively); inhibits tumor growth in a MOLM-13 mouse xenograft model at 25 mg/kg
Cayman Chemical ANTIBODY CU-32 10mg
A cGAS inhibitor (IC50 = 0.45 µM); reduces DNA-, but not Sendai virus-, induced IRF3 dimerization in THP-1 cells, indicating cGAS pathway selectivity; selective for cGAS over TLRs at 50 µM; decreases IFN-stimulatory DNA-induced IFN-β production in THP-1 cells at 10, 30, and 100 µM
Medchemexpress LLC Nrp1 antagonist 1 | 2569598-01-0 | MFCD35061294 | 99.7% | C22H22N6OS2 | 10MG
NRP1 antagonist 1 is a small-molecule neuropilin-1 (NRP1) antagonist supplied for research use. It inhibits NRP1 with an IC50 of 19.1 μM, has molecular formula C22H22N6OS2 and molecular weight 450.58, and is provided as high-purity material suitable for cancer-related biological studies.
- Demonstrated NRP1 inhibition (IC50 19.1 μM).
- High purity for reliable biochemical and cell-based assays (99.7%).
- Available in multiple pack sizes and in DMSO solution formats.
- Suitable as a small-molecule tool for cancer research applications.
- Accompanied by datasheet, COA, and SDS for quality and handling information.
Cayman Chemical Reserplne 5mg
An indole alkaloid; decreases amphetamine-induced hyperactivity in mice at 12.5 and 25 mg/kg
Selleck Chemical LLC Semen Lablab Album Extract E3012-5MG
Semen Lablab Album Extract is extracted from Baibiandouren (Lablab Semen Album) a white seed from the leguminosae plant Dolichos lablab L Tuchao Baibiandouren (Lablab Semen Album fried with earth TCBBDR) exerts therapeutic effects on diabetes through multi-compound and multi-target collaboration
Cayman Chemical ANTIBODY AR-7 5mg
A RARα antagonist; increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability in mouse fibroblasts at 20 μM; selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively)