Bioactive Small Molecules
AdipoGen Harzianum A (250 µg)
Chemical. CAS: 156250-74-7. Formula: C23H28O6. MW: 400.4. Isolated from Trichoderma sp. Antifungal. Anticancer compound. Cytotoxic to human cancer cell lines.
AdipoGen alpha-Mannosylceramide (1 mg)
Chemical. CAS: 320610-63-7. Formula: C50H99NO9. MW: 858.3. Potent stimulator of natural killer T (NKT) cells expressing the invariant Valpha19-Jalpha26 T cell receptor alpha chain (Valpha19 NKT cells).
AdipoGen Celastrol (50 mg)
Chemical. CAS: 34157-83-0. Formula: C29H38O4. MW: 450.6. Isolated from Tripterygium wilfordii. Anti-obesity agent. Potent leptin sensitizer. Antioxidant. Potent lipid peroxidation inhibitor. NADPH oxidases (NOX1, 2, 4 and 5) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. HSP90 inhibitor and HSP70 inducer. Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways. Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway. Topoisomerase II inhibitor. 20S proteasome chymotrypsin-like activity inhibitor. Potential antiviral and anti-Alzheimer's agent.
AdipoGen H-89 . dihydrochloride (25 mg)
Chemical. CAS: 130964-39-5 | 127243-85-0 (free base). Formula: C20H20BrN3O2S . 2HCl. MW: 446.4 . 72.9. Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Review.
AdipoGen Wortmannin (1 mg)
Chemical. CAS: 19545-26-7. Formula: C23H24O8. MW: 428.4. Isolated from Penicillium sp. Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Similar potency in vitro for the class I, II, and III PI3K. Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor, regardless of the nutrient status and thus is a more suitable autophagy inhibitor than 3-MA. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. TRAIL sensitizer
AdipoGen Mycophenolic acid (500 mg)
Chemical. CAS: 24280-93-1. Formula: C17H20O6. MW: 320.3. Isolated from Penicillium brevi-compactum. Antibiotic. Shows antiviral, antifungal and antitumor properties. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform. Inhibits RNA and DNA synthesis. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor. Apoptosis and necrosis inducer. Novel type of inhibitor against RNA guanylyltransferases. Inhibits TNF-alpha-stimulated MAPK/NF-kappaB and ROS generation.
AdipoGen Cytostatin (250 µg)
Chemical. CAS: 457070-06-3 | 682329-63-1 (free base). Formula: C21H32NaO7P. MW: 450.4. Isolated from Streptomyces sp. MJ654-NF4. Potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Antitumor agent. Antimetastatic. Apoptosis inducer.
AdipoGen Ingenol-5,20-acetonide (1 mg)
Chemical. CAS: 77573-43-4. Formula: C23H32O5. MW: 388.5. Semisynthetic. Intermediate and starting material for the synthesis and preparation of ingenol 3-ester derivatives. For use in chemical synthesis see references. Has improved shelf life compared to ingenol.
AdipoGen (R,R)-Hymeglusin (0.5 mg)
Chemical. CAS: 29066-42-0. Formula: C18H28O5. MW: 324.4. Isolated from fungal strain Scopulariopsis sp. F-244. beta-Lactone antibiotic. Antibacterial and antifungal. Specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme. Mevalonate biosynthesis inhibitor.
AdipoGen Cyclosporin C (5 mg)
Chemical. CAS: 59787-61-0. Formula: C62H111N11O13. MW: 1218.6. Isolated from Fusarium solani. Immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Antifungal. Antitumor.