Crosslinking, Labeling and Protein Modification
Cayman Chemical nrIdronIc AcId 50mg
An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.
Aat Bioquest Sulfo-SMCC [4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester, sodium salt] *CAS#: 92921-24-9*
Sulfo-SMCC is the water-soluble version of SMCC. It contains an amine-reactive sulfo-succinimidyl ester (SSE) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds.
Cayman Chemical Latnoprostfree acId 50mg
An FP receptor agonist and active metabolite of latanoprost; selectively binds to the FP receptor (Ki = 0.098 µM) over the EP1, EP2, EP3, and EP4 receptors (Kis = 2.06, 39.667, 7.519, and 75 µM, respectively), as well as the DP, IP, and TP receptors (Kis = ≥20, ≥90, and ≥60 µM, respectively); induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells, mouse NIH3T3 fibroblasts, and rat A7r5 vascular smooth muscle cells, which all endogenously express FP receptors (EC50s = 124, 35, 32, and 35 nM, respectively), as well as HEK293 cells expressing human ocular FP receptors (EC50 = 45.7 nM); increases intracellular calcium levels in hEP1-5/293-AEQ17 cells expressing EP1 receptors in an aequorin-based calcium assay (EC50 = 119 nM); induces contraction of isolated cat iris sphincter smooth muscle (EC50 = 29.9 nM)
Cayman Chemical SulfosuccInImIdyl 32 BIot 25mg
An amine-reactive reagent; has been used as a derivatization reagent to identify PTMs in lysine-rich proteins and novel cell surface proteins of R. rickettsii
Cayman Chemical 1R 3R3BenzoIc acId 3carb 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical 4chloroaCynocInamIc AcId 50mg
A phenylpropanoid which readily co-crystallizes with various biomolecules
Cayman Chemical EZ-4-hydroxy TamoxIfen 50mg
A mixture of (E)-4-hydroxy tamoxifen and (Z)-4-hydroxy tamoxifen; (Z)-4-hydroxy Tamoxifen (100 nM) inhibits 17β-estradiol-induced increases in the mRNA encoding progesterone receptor in MCF-7 cancer cells at 100 nM; (Z)-4-hydroxy Tamoxifen inhibits the proliferation of MCF-7 and MDA-MB-231 cancer cells (IC50s = 27 and 18 µM, respectively)
Medchemexpress LLC DBCO-Sulfo-Link-biot 5mg
DBCO-Sulfo-Link-biotin TEA is a click chemistry intermediate containing a DBCO group which can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group
Medchemexpress LLC trans-Sulfo-SMCC | 1286837-77-1 | 90.9% | 414.39 g·mol⁻1 | C16H18N2O9S | 5 MG
trans-Sulfo-SMCC is a non-cleavable, membrane-permeable antibody-drug conjugate (ADC) crosslinker containing an NHS ester and a maleimide reactive group. It is supplied as a solid for research use in bioconjugation and ADC development.
- Non-cleavable crosslinker for stable conjugation
- Membrane-permeable design suitable for intracellular labeling
- Reacts with primary amines and sulfhydryls via NHS ester and maleimide
- Supplied as an off-white to white solid powder
- Stable when stored at -20°C in powder form
Lumiprobe CY5.5 NHS ESTER 25MG
Near infrared cyanine dye which is ideal for bioimaging applications. Amine-reactive dye for the labeling of peptides and amino-oligonucleotides. For the labeling of sensitive proteins, use water-soluble sulfo-Cyanine5 NHS ester.