Crosslinking Reagents
Crosslinking Reagents
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Filtered Search Results
Thermo Scientific™ Pierce™ EDC, No-Weigh™ Format
Immobilize or conjugate proteins using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (CAS 25952-53-8), a water-soluble, carboxyl-to-amine crosslinker.
Shipping Condition | Wet Ice |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | EDC |
Cleavable | No |
Water Soluble | Yes |
Form | Powder |
Molecular Weight (g/mol) | 191.7 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Carboxyl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 Å) |
Reactive Moiety | Carbodiimide |
Spacer Arm Length | 0.0 Å |
PEGylated | No |
Thermo Scientific™ NHS (N-hydroxysuccinimide)
Prepare amine-reactive NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysuccinimide, CAS 6066-82-6.
Thermo Scientific™ DSS (disuccinimidyl suberate), No-Weigh™ Format
Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.
Cleavable | No |
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PEGylated | No |
Thermo Scientific™ Pierce™ Premium Grade EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride)
Optimize applications where product integrity and risk minimization are paramount with this high-quality formulation of carbodiimide crosslinker.
Content And Storage | Upon receipt store desiccated at -20°C. |
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Description | EDC |
Cleavable | No |
Water Soluble | Yes |
Molecular Weight (g/mol) | 191.7 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Carboxyl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 Å) |
Reactive Moiety | Carbodiimide |
Spacer Arm Length | 0.0 Å |
Product Line | Pierce™ |
PEGylated | No |
Thermo Scientific™ BMH (bismaleimidohexane)
Crosslink sulfhydryls to sulfhydryls (cysteine residues in proteins or peptides) with this long crosslinker composed of maleimide groups and 11-atom (13.0A) spacer arm.
Thermo Scientific™ Pierce™ DSP, No-Weigh™ Format
Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.
Content And Storage | Upon receipt store desiccated at 4°C. |
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Description | DSP |
Cleavable | By Thiols |
Water Soluble | No |
Form | Powder |
Molecular Weight (g/mol) | 404.42 |
Solubility | DMF, DMSO |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 Å) |
Reactive Moiety | NHS Ester |
Spacer Arm Length | 12.0 Å |
PEGylated | No |
Description | DSG |
---|---|
Cleavable | No |
Water Soluble | No |
Form | Powder |
Molecular Weight (g/mol) | 326.26 |
Solubility | DMF, DMSO |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Short (<10 Å) |
Reactive Moiety | NHS Ester |
Spacer Arm Length | 7.7 Å |
PEGylated | No |
Thermo Scientific™ SMPB (succinimidyl 4-(p-maleimidophenyl)butyrate)
Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of an aromatic, 10-atom (11.6A) spacer arm.
Thermo Scientific™ Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate))
Crosslink amines to amines with a crosslinker composed of sulfo-NHS-ester groups and hydroxylamine-cleavable spacer arm; water-soluble for cell-surface protein crosslinking.
Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.
Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format
Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.
Shipping Condition | Ambient |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | Sulfo-SMCC |
Cleavable | No |
Water Soluble | Yes |
Molecular Weight (g/mol) | 436.37 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Sulfhydryl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 Å) |
Reactive Moiety | Maleimide, Sulfo-NHS Ester |
Spacer Arm Length | 8.3 Å |
PEGylated | No |
Thermo Scientific™ BS3 (bis(sulfosuccinimidyl)suberate)
Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.
Cleavable | No |
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Molecular Weight (g/mol) | 572.43 |
Solubility | Water |
PEGylated | No |
Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)
Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).
Shipping Condition | Ambient |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | SM(PEG)2 |
Cleavable | No |
Water Soluble | Yes |
Form | Solid |
Molecular Weight (g/mol) | 425.39 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Sulfhydryl |
Cell Permeability | No |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 Å) |
Reactive Moiety | Maleimide, NHS Ester |
Spacer Arm Length | 17.6 Å |
Product Line | Pierce™ |
PEGylated | Yes |
Thermo Scientific™ DTSSP (3,3'-dithiobis(sulfosuccinimidyl propionate))
Crosslink amines to amines with Sulfo-DSP; composed of sulfo-NHS-ester groups and disulfide spacer arm (12.0A) that is cleavable with reducing agents.