Protein Modification Reagents
Medchemexpress LLC Mal-PEG4-val-cit-pab | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 25 MG
Mal-PEG4-Val-Cit-PAB is a protease-cleavable antibody-drug conjugate (ADC) linker containing a maleimide reactive group and a PEG4 spacer. It is intended for use in the synthesis of ADCs to attach payloads to antibodies via a Val-Cit-PAB cleavable sequence.
- Cleavable Val-Cit-PAB dipeptide is protease sensitive.
- Maleimide reactive group enables thiol conjugation.
- PEG4 spacer improves solubility and reduces aggregation.
- Molecular weight 777.86 and formula C36H55N7O12.
- High purity typically near 98.9% and provided as a solid.
eMolecules Fmoc-NH-PEG5-CH2COOH | 635287-26-2 | MFCD26142982 | 1g
Ambeed | Fmoc-NH-PEG5-CH2COOH | 1g | 506391038 | A474989 | | 635287-26-2 | MFCD26142982 | 517.575 | C27H35NO9
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Medchemexpress LLC (2S,4R)-1-((S)-14-Azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-( | 1797406-80-4 | MFCD31807299 | >95.0% | 645.77 g/mol | C30H43N7O7S | 5 MG
(S,R,S)-AHPC-PEG3-N3 is an azide-terminated VHL ligand-linker conjugate that combines an (S,R,S)-AHPC VHL ligand with a three-unit polyethylene glycol linker. It is intended for use in PROTAC design, click-chemistry conjugation, and other chemical biology applications, and is supplied in small milligram quantities with manufacturer-verified purity and storage recommendations.
- Provides an azide-terminated PEG3 linker for click chemistry conjugation.
- Designed to recruit the von Hippel-Lindau (VHL) E3 ligase for targeted protein degradation studies.
- Supplied in accurately weighed milligram quantities suitable for medicinal chemistry workflows.
- Manufacturer certificate of analysis confirms purity and storage conditions for long-term stability.
Medchemexpress LLC DSPE-PEG-DBCO sodium | 99.6% | 3400 (average) | 5 MG
DSPE-PEG-DBCO sodium (MW 3400) is a DBCO-functionalized PEGylated phospholipid supplied as a white to off-white solid. It provides a bioorthogonal DBCO handle for strain-promoted azide-alkyne cycloaddition (SPAAC) and an amphiphilic DSPE-PEG backbone suitable for incorporation into liposomes and lipid nanoparticles for surface functionalization and delivery research.
- Provides DBCO handle for copper-free click conjugation.
- Enables surface functionalization of liposomes and nanoparticles.
- Amphiphilic PEG-lipid backbone supports stable lipid formulations.
- PEG chain (average MW 3400) imparts steric stabilization and solubility.
- Supplied as a solid suitable for small-scale research use.
- Available in small packaged quantities for laboratory experiments.
eMolecules PEG5-Ms | 65883-12-7 | MFCD29042357 | 1g
Broadpharm | PEG5-Ms | 1g | 296213416 | BP-22906 | 98.000 | 65883-12-7 | MFCD29042357 | 272.310 | C9H20O7S
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Medchemexpress LLC Azido-PEG1-C2-acid | 1393330-34-1 | 98.0% | 159.14 | 50MG
Azido-PEG1-C2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group. This enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules, and it can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group for click chemistry reactions
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Propargyl-PEG4-5-nitrophenyl carbonate | 1422540-81-5 | 98.2% | 397.38 | 50 MG
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC Rhodamine B PEG2-NH2 | 95.3% | 566.13 | 25 MG
Rhodamine B PEG2-NH2 is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. These PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. For research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates targeted protein degradation
Medchemexpress LLC Biotin-PEG4-amide-Alkyne | 1006592-45-5 | 96.41% | C24H40N4O7S | 100 MG
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. PROTACs themselves are compounds that feature two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein of interest. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Can be used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Allows for selective degradation of target proteins.
Chemscene ChemScene | NH2-PEG3-C2-NH-Boc | 5G | CS-0032897 | 0.97 | 101187-40-0| MFCD16619220 | 292.37
ChemScene | NH2-PEG3-C2-NH-Boc | 5G | CS-0032897 | 0.97 | 101187-40-0| MFCD16619220 | 292.37
Medchemexpress LLC Mal-PEG2-VCP-NB | 2395887-69-9 | 98.3% | 783.78 g/mol | C36H45N7O13 | 50 MG
Mal-PEG2-VCP-NB is a cleavable antibody-drug conjugate (ADC) linker featuring a maleimide reactive group, a two-unit polyethylene glycol (PEG2) spacer, and a VCP NB moiety. It is supplied as a research chemical for ADC conjugation and formulation studies.
- Cleavable ADC linker containing a maleimide reactive group.
- Two-unit PEG spacer to improve solubility and flexibility.
- VCP NB moiety for payload attachment.
- Purity 98.25% and molecular weight 783.78 g/mol.
- Soluble in DMSO (100 mg/mL); sonication may be required.
- Supplied as a 50 mg powder; store at 4°C under nitrogen; in solution store -80°C up to 6 months.
Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 25 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein, and they degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an Azide group for CuAAc reactions
- Participates in SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.4% | 100 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Ligands target E3 ubiquitin ligase and target protein
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Ethanol, 2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]- | 1807520-99-5 | 97.9% | C14H21N3O8 | 100 MG
DNP-PEG4-alcohol is a chemical compound commonly utilized as a PROTAC linker, playing a crucial role in proteolysis-targeting chimera (PROTAC) technology. This molecule is designed to facilitate targeted protein degradation by connecting a ligand that binds to a target protein with another ligand that recruits an E3 ubiquitin ligase. The PEG4 chain enhances solubility and provides conformational flexibility to optimize PROTAC efficacy.
- Acts as a PROTAC linker
- Facilitates targeted protein degradation
- Enhances solubility
- Provides conformational flexibility