Protein Modification Reagents
Medchemexpress LLC Thiol-PEG4-NH2 hydrochloride | 2762393-21-3 | 95.0% | 289.82 | 100 MG
Thiol-PEG4-NH2 hydrochloride is a PEG-based PROTAC linker suitable for the synthesis of PROTACs. PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![eMolecules Broadpharm / 18-(Amine-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester / 100mg / 784454994 / BP-29798 / 95.000 / / [null] / 544.818 / C30H60N2O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473325.JPG-250.jpg)
eMolecules Broadpharm / 18-(Amine-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester / 100mg / 784454994 / BP-29798 / 95.000 / / [null] / 544.818 / C30H60N2O6
Broadpharm / 18-(Amine-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester / 100mg / 784454994 / BP-29798 / 95.000 / / [null] / 544.818 / C30H60N2O6
Medchemexpress LLC DSPE-PEG-CHO (aldehyde-terminated DSPE-PEG) | 2000 (average) | 10 MG
DSPE-PEG-CHO (MW 2000) is a heterobifunctional PEGylated phospholipid composed of a DSPE lipid anchor linked to a polyethylene glycol chain terminated with an aldehyde group. Supplied as a powder, it is designed for introducing reactive aldehyde functionality onto liposomes, lipid nanoparticles, or other lipid-based carriers to enable conjugation of biomolecules for targeted delivery and surface modification.
- Aldehyde-terminated PEG enables covalent conjugation to primary amines.
- PEG MW 2000 provides hydrophilicity and steric stabilization of particles.
- DSPE lipid anchor facilitates efficient incorporation into lipid bilayers and nanoparticles.
- DMSO solubility approximately 12.5 mg/mL with ultrasonic warming to 60°C.
- Powder storage at -20°C (up to 3 years); in solvent storage at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 25 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds designed to degrade target proteins by exploiting the intracellular ubiquitin-proteasome system; they achieve this by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Degrades target proteins
- Exploits intracellular ubiquitin-proteasome system
- Connects a ligand for an E3 ubiquitin ligase with a ligand for the target protein
Broadpharm Azido-PEG5-Val-Cit-PAB-OH, 500 mg, 98% purity, Cleavable linker, Enzymatic cleavage with Val-Cit, Azide reactive group
Azido-PEG5-Val-Cit-PAB-OH, 500 mg, 98% purity, Cleavable linker, Enzymatic cleavage with Val-Cit, Azide reactive group
eMolecules Medchem Express / Biotin-PEG4-NHS ester / 50mg / 527574014 / HY-140889 / / 459426-22-3 / MFCD08458915 / 588.670 / C25H40N4O10S
Medchem Express / Biotin-PEG4-NHS ester / 50mg / 527574014 / HY-140889 / / 459426-22-3 / MFCD08458915 / 588.670 / C25H40N4O10S
Broadpharm Iodoacetamido-PEG6-azide| 100mg| 1240737-77-2| Purity 98%
Iodoacetamido-PEG6-azide| 100mg| 1240737-77-2| Purity 98%
Medchemexpress LLC DOTA-PEG5-C6-DBCO | 97.9% | C49H71N7O14 | 25 MG
DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs consist of two ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein, utilizing the intracellular ubiquitin-proteasome system for selective protein degradation. This product is for research use only.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group for SPAAC with azide groups
- Molecular weight of 982.13
- Chemical formula C49H71N7O14
- Off-white to light yellow solid appearance
- High purity of 97.9%
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | 99.8% | 634.56 g/mol | C24H48BrN3O11 | 50 MG
N3-PEG11-CH2CH2Br is a polyethylene glycol (PEG11) linker with an azide (N3) terminus and a bromide-functionalized ethylene spacer. It is a hydrophilic, viscous liquid used in bioconjugation and click-chemistry workflows to improve aqueous solubility and provide a reactive bromide handle for further modification.
- Azide-terminated PEG11 linker for click chemistry.
- Bromide-functionalized ethylene spacer provides a reactive handle.
- Hydrophilic PEG spacer increases solubility in aqueous media.
- High purity suitable for research applications.
- Recommended storage conditions maintain stability.
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | MFCD13184948 | >90% | 388.37 g/mol | C15H24N4O8 | 50 MG
N3-PEG4-C2-NHS ester is an azide-functionalized, non-cleavable polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester for amine coupling and an azide (N3) group for click chemistry applications such as antibody-drug conjugate (ADC) synthesis and bioconjugation.
- Azide-functionalized 4-unit PEG linker suitable for bioconjugation.
- N-hydroxysuccinimide (NHS) ester for efficient amine coupling.
- Compatible with copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High solubility in DMSO; stock solutions commonly prepared per datasheet guidance.
- Storage recommendations: pure form -20°C up to 3 years; in solvent -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Azido-AHPC-PEG3 (VHL ligand-linker) pyrrolidine-2-carboxamide | 1797406-80-4 | MFCD31807299 | ≥95.0% | 645.77 g/mol | C30H43N7O7S | 10 MG
(S,R,S)-AHPC-PEG3-N3 is an E3 ligase ligand-linker conjugate that couples an (S,R,S)-AHPC VHL-binding motif to a three-unit PEG linker terminated with an azide. It is intended as a click-chemistry reagent for PROTAC synthesis and bioconjugation, enabling covalent linkage to alkyne-bearing partners.
- Molecular weight 645.77 g/mol.
- Chemical formula C30H43N7O7S.
- CAS number 1797406-80-4.
- Purity ≥95%.
- Suitable for CuAAC and SPAAC click reactions.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Soluble in ethanol, water, and DMSO at concentrations commonly used for bioconjugation.
Medchemexpress LLC (S,R,S)-AHPC-PEG2-NH2 dihydrochloride | 2341796-76-5 | 648.64 g/mol | C28H43Cl2N5O6S | 100 MG
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride is a VHL E3 ligase ligand-linker conjugate used as a building block in PROTAC synthesis. It combines an (S,R,S)-configured AHPC VHL ligand with a two-unit PEG linker terminating in a primary amine and is supplied as a dihydrochloride salt in powder form for research use.
- VHL ligand-linker conjugate for PROTAC assembly.
- Two-unit PEG linker with terminal primary amine.
- Dihydrochloride salt stable as a sealed powder.
- Supplied in small milligram quantities for medicinal chemistry workflows.
- Suitable as a synthetic building block in degrader design.
eMolecules M-PEG3-TOS | AstaTech | 50586-80-6 | MFCD13184964 | 274.330 | C12H18O5S | 95.000 | COCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 402181567
M-PEG3-TOS | AstaTech | 50586-80-6 | MFCD13184964 | 274.330 | C12H18O5S | 95.000 | COCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 402181567
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g/mol | C57H75N9O21 | 100 MG
Azide-PEG4-VC-PAB-doxorubicin is an azide-functionalized drug-linker conjugate that links the cytotoxic agent doxorubicin to a PEG4-VC-PAB linker for use in antibody-drug conjugate synthesis and click chemistry applications.
- High purity (99.62%).
- Molecular weight 1222.25 g/mol.
- Chemical formula C57H75N9O21.
- Orange to red solid appearance.
- Storage: powder at -20°C (long term) or 4°C (short term); in solvent at -80°C or -20°C as recommended.
- Available as solid (1-100 mg) and 10 mM solution in DMSO.
Cayman Chemical -BIotIn-PEG3-amIn 250mg
A synthetic intermediate; has been used in the synthesis of biotinylated siderophores for whole-cell bacterial pull-down assays, as well as in the synthesis of protein-polysaccharide conjugate vaccines for S. pneumoniae