Protein Modification Reagents

Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 25 MG

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A cleavable, PEG-based linker containing an azide functional group and a terminal amino group for bioconjugation. Designed as an 11-unit PEG spacer, it provides hydrophilicity and reactive handles for click chemistry and antibody-drug conjugate synthesis.

• Cleavable 11-unit PEG linker providing hydrophilic spacer.
• Contains an azide group for copper-catalyzed and strain-promoted click reactions.
• Terminal amino group enables further conjugation chemistry.
• Suitable for antibody-drug conjugate and bioconjugation applications.
• Available in small lab pack sizes for research use.

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eMolecules​ Broadpharm / Methyltetrazine-PEG4-STP Ester / 10mg / 795362051 / BP-40299 / / / [null] / 686.560 / C26H27F4N4NaO10S

Broadpharm / Methyltetrazine-PEG4-STP Ester / 10mg / 795362051 / BP-40299 / / / [null] / 686.560 / C26H27F4N4NaO10S

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eMolecules​ Broadpharm Fmoc-N-amido-PEG4-acid 500mg 208940413 BP-20989 98 000 557756-85-1 MFCD06656472 487 549 C26H33NO8

Broadpharm Fmoc-N-amido-PEG4-acid 500mg 208940413 BP-20989 98 000 557756-85-1 MFCD06656472 487 549 C26H33NO8

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Medchemexpress LLC Hs-peg6-ch2ch2-boc | 1818294-40-4 | MFCD26127815 | 95.0% | 426.57 g/mol | C19H38O8S | 5 MG

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HS-PEG6-CH2CH2-Boc is a PEG-based linker bearing a thiol terminus and a Boc-protected terminus, designed for use in the synthesis of PROTACs and other bifunctional molecules. It provides a flexible, hydrophilic spacer useful for connecting ligands while maintaining solubility and synthetic handle orthogonality.

• Suitable for use in PROTAC and bifunctional molecule synthesis.
• Thiol terminus enables selective conjugation to thiol-reactive partners.
• PEG6 spacer provides flexibility and improved aqueous solubility.
• Boc-protected terminus allows orthogonal protection and selective deprotection.
• Molecular formula C19H38O8S; molecular weight 426.57 g/mol.

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Medchemexpress LLC N3-PEG3-VC-PAB-MMAF | 2757277-32-8 | 100.0% | 1352.62 | C66H105N13O17 | 25 MG

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N3-PEG3-VC-PAB-MMAF is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines an azide-functionalized PEG3 spacer, a valine-citrulline (VC) cleavable linker with a para-aminobenzyl (PAB) self-immolative spacer, and the tubulin inhibitor MMAF to enable click chemistry conjugation and controlled payload release.

• Azide-functionalized PEG3 spacer for click chemistry conjugation.
• VC-PAB cleavable linker enabling enzymatic release of payload.
• Includes MMAF payload for tubulin inhibition in ADC constructs.
• White to off-white solid with high purity suitable for research use.
• Available in small milligram pack sizes for synthesis workflows.

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Medchemexpress LLC TCO-PEG4-VC-PAB-MMAE | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 10 MG

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TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) assembly and click-chemistry bioconjugation workflows. It combines a trans-cyclooctene (TCO) click handle, a PEG4-Val-Cit-PAB cleavable linker, and the cytotoxic payload MMAE to enable site-selective conjugation and intracellular release of the payload.

• Provides a trans-cyclooctene (TCO) handle for inverse electron-demand Diels-Alder reactions with tetrazines.
• Contains a PEG4-Val-Cit-PAB cleavable linker for enzymatic payload release.
• Conjugated to MMAE to supply a potent cytotoxic payload for ADC research.
• High purity (99.3%) suitable for research and bioconjugation workflows.
• Characterized by molecular weight 1522.91 and formula C78H127N11O19.

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eMolecules​ Broadpharm / 14-(Amine-PEG3-ethylcarbamoyl)tridecanoic t-butyl ester / 100mg / 784455746 / BP-40052 / 95.000 / / [null] / 488.710 / C26H52N2O6

Broadpharm / 14-(Amine-PEG3-ethylcarbamoyl)tridecanoic t-butyl ester / 100mg / 784455746 / BP-40052 / 95.000 / / [null] / 488.710 / C26H52N2O6

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Medchemexpress LLC Diketone-PEG4-biotin | 2353409-85-3 | 95.0% | C33H50N4O9S | 10MG

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Diketone-PEG4-Biotin is a PEG-based PROTAC linker bearing a biotin affinity tag for use in chemical biology and targeted protein degradation research. It provides a flexible, water-soluble spacer to enable conjugation and affinity capture in the synthesis of bifunctional molecules and assay workflows.

• Peg-based linker with biotin for affinity capture.
• Compatible with PROTAC synthesis and bifunctional conjugates.
• Provides a flexible spacer to reduce steric hindrance.
• Facilitates pull-down assays and target engagement studies.
• Supplied with specified purity for research applications.
• Available in small research pack sizes for method development.

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Medchemexpress LLC Dspe-peg-amine (ammonium) | 474922-26-4 | 98.8% | 1000 (average) | (C2H4O)nN2O10P·NH3 | 25 MG

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DSPE-PEG-Amine (average MW 1000, ammonium salt) is a PEGylated phospholipid with a terminal primary amine used to functionalize liposomes and nanoparticles. The hydrophobic DSPE anchor incorporates into lipid bilayers while the PEG spacer presents a reactive amine at the particle surface for covalent conjugation to ligands, dyes, or biomolecules in delivery and surface-modification applications.

• PEGylated phospholipid with terminal primary amine.
• Average molecular weight approximately 1000 daltons.
• Ammonium salt form to aid handling and solubility.
• Enables covalent conjugation to NHS-esters, aldehydes, and other activated groups.
• Integrates into liposome bilayers for surface functionalization.
• Suitable for nanoparticle coating and targeted delivery research.

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Nanocs DSPE PEG Thiol, DSPE-PEG-SH, 3400 Da, 100mg

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated Polyethylene Glycol, DSPE PEG is a phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

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eMolecules​ Broadpharm / DSPE-PEG-Boronate MW 3400 / 100mg / 718091659 / BP-28212 / 90.000 / / [null] / 1045.130 / C53H95BFN2O14P

Broadpharm / DSPE-PEG-Boronate MW 3400 / 100mg / 718091659 / BP-28212 / 90.000 / / [null] / 1045.130 / C53H95BFN2O14P

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eMolecules​ Bromoacetamido-PEG5-Propargyl | 1807521-10-3 | MFCD28064329 | 500mg

Broadpharm | Bromoacetamido-PEG5-Propargyl | 500mg | 550804089 | BP-22203 | 98.000 | 1807521-10-3 | MFCD28064329 | 396.278 | C15H26BrNO6

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Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | MFCD13184948 | 98.9% | 388.37 g/mol | C15H24N4O8 | 100 MG

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N3-PEG4-C2-NHS ester is an azide-terminated polyethylene glycol (PEG4) N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation and click-chemistry applications, including antibody-drug conjugate assembly and labeling of biomolecules.

• Azide functional group enables copper-catalyzed and strain-promoted click reactions.
• NHS ester reacts readily with primary amines to form stable amide bonds.
• Peg4 spacer provides hydrophilicity and conformational flexibility.
• High purity supports reliable research-grade conjugation.
• Stability under recommended cold-storage conditions for long-term use.

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eMolecules​ Amino-PEG8-amine | 82209-36-7 | MFCD28122964 | 1g

Broadpharm | Amino-PEG8-amine | 1g | 254745498 | BP-22251 | 98.000 | 82209-36-7 | MFCD28122964 | 412.524 | C18H40N2O8

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Medchemexpress LLC S R S-Ahpc-Peg4-Nh2 5Mg | HY-103604-5MG

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S R S-Ahpc-Peg4-Nh2 5Mg

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