Protein Modification Reagents
Medchemexpress LLC Pomalidomide-PEG2-acetic acid | 2143097-05-4 | 99.4% | 419.39 g·mol⁻1 | C19H21N3O8 | 10 MG
Pomalidomide-PEG2-acetic acid is a pomalidomide-derived cereblon E3 ligase ligand-linker conjugate that incorporates a short PEG2 spacer terminated with an acetic acid (-CH2COOH) functional group for conjugation. It is supplied as a solid building block intended for PROTAC synthesis and related coupling chemistries.
- Used as an E3 ligase ligand-linker building block for PROTAC synthesis.
- PEG2 linker with a terminal acetic acid group for amide or ester coupling.
- High purity (99.43%).
- Molecular formula C19H21N3O8 and molecular weight 419.39 g·mol⁻1.
- CAS number 2143097-05-4.
- Available in mg-scale quantities for synthetic applications.
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 250 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (proteolysis-targeting chimeras) exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Facilitates selective degradation of target proteins
- Molecular weight: 295.33
- Chemical formula: C12H25NO7
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 | C22H35NO8 | 25 MG
Endo-BCN-PEG4-acid is a cleavable four-unit PEG linker containing a bicyclononyne (BCN) group and a terminal carboxylic acid. It is used as a linker in antibody-drug conjugate (ADC) synthesis and as a reagent for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Cleavable 4-unit polyethylene glycol (PEG) linker.
- Contains a BCN group for SPAAC click chemistry.
- Terminal carboxylic acid enables conjugation to amines or alcohols.
- High purity suitable for bioconjugation reactions.
- Colorless to light yellow liquid physical form.
- Long-term storage recommended at -20°C (pure form) or lower when in solution.
Medchemexpress LLC Dbco-peg4-val-cit-pab-mmaf | 2244602-23-9 | 98.7% | 1672.01 g/mol | C88H126N12O20 | 5 MG
DBCO-PEG4-Val-Cit-PAB-MMAF is a cleavable linker-payload conjugate used for antibody-drug conjugate synthesis and bioconjugation. The construct combines a DBCO bioorthogonal handle, a PEG4 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a PAB self-immolative spacer, and an MMAF cytotoxic payload. Analytical documentation and handling instructions are available.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) via DBCO for click chemistry.
- Peg4 spacer increases hydrophilicity and reduces aggregation.
- Val-Cit dipeptide is cleavable by cathepsin enzymes for controlled payload release.
- PAB self-immolative spacer allows rapid payload liberation after cleavage.
- Contains MMAF, a tubulin inhibitor payload for ADC applications.
- High reported purity with supporting analytical data and safety documentation.
Medchemexpress LLC PTDA-PEG4-azide | 2639395-40-5 | 99.3% | 539.54 | C22H33N7O9 | 5 MG
PTDA-PEG4-azide is a PEG4-linked azide reagent used as an ADC linker and for click-chemistry bioconjugation in research applications. The compound is supplied as a white to off-white oil with high purity and is provided in small, research-scale quantities.
- High purity (99.3%).
- Molecular weight 539.54 g/mol.
- Molecular formula C22H33N7O9.
- Soluble in DMSO at 125 mg/mL; ultrasonic assistance recommended; use freshly opened DMSO.
- Storage: pure form -20°C (stable for 3 years); in solvent -80°C (6 months), -20°C (1 month).
- Available in small pack sizes suitable for research use.
Medchemexpress LLC Tetrazine-PEG4-amine hydrochloride | 2752945-36-9 | 99.8% | 470.95 g/mol | C20H31ClN6O5 | 5 MG
Tetrazine-PEG4-amine hydrochloride is a cleavable four-unit polyethylene glycol (PEG) linker containing a tetrazine functional group used as a click-chemistry reagent for inverse electron-demand Diels-Alder (iEDDA) reactions and in the synthesis of antibody-drug conjugates. For research use only.
- Cleavable four-unit PEG linker for ADC synthesis.
- Tetrazine group enables fast iEDDA click chemistry with TCO partners.
- Solid form with high purity (≈99.8%).
- Molecular weight 470.95 g/mol; formula C20H31ClN6O5.
- Soluble in methanol (≈250 mg/mL); may require sonication.
- Store sealed at -20°C; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
eMolecules Hydroxy-PEG3-t-butyl ester | Broadpharm | 186020-66-6 | MFCD03791106 | 278.345 | C13H26O6 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCO | 5g | 112541344
Hydroxy-PEG3-t-butyl ester | Broadpharm | 186020-66-6 | MFCD03791106 | 278.345 | C13H26O6 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCO | 5g | 112541344
Medchemexpress LLC Propargyl-PEG4-sulfonic acid | 1817735-29-7 | 98.0% | 296.34 | 5 G
Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Bis-PEG4-NHS ester | 1g
Bis- PEG4- NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC)