Protein Modification Reagents

eMolecules​ 557756-85-1 | Fmoc-N-amido-PEG4-acid | Combi-Blocks | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 117553694

Fmoc-N-amido-PEG4-acid | Combi-Blocks | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 117553694

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eMolecules​ 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 799175051

Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 799175051

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Medchemexpress LLC Dspe-peg-nhs | MFCD03098978 | 80.0% | 5,000 Da | 50 MG

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DSPE-PEG-NHS, MW 5000, is a pegylated phospholipid bearing an N-hydroxysuccinimide (NHS) reactive ester at the PEG terminus. The reagent (average MW 5,000 Da) provides an amine-reactive linker for covalent attachment of ligands to liposomes and lipid nanoparticles, while the PEG chain imparts steric stabilization and reduced protein adsorption, making it useful for formulation and bioconjugation research.

• Provides an NHS ester for covalent coupling to primary amines.
• Imparts PEGylation for steric stabilization and reduced protein adsorption.
• Enables liposome and nanoparticle surface functionalization.
• Average molecular weight approximately 5,000 Da.
• Typical purity reported as 80.0%.
• Suitable for bioconjugation and targeted drug-delivery research.

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eMolecules​ 811442-84-9 | t-Boc-N-amido-PEG4-amine | Broadpharm | MFCD16619339 | 336.429 | C15H32N2O6 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN | 500mg | 272383834

t-Boc-N-amido-PEG4-amine | Broadpharm | 811442-84-9 | MFCD16619339 | 336.429 | C15H32N2O6 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN | 500mg | 272383834

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eMolecules​ 2855229-28-4 | Hydroxy-PEG1-acid sodium salt | Broadpharm156.113 | C5H9NaO4 | 0.000 | [Na+].OCCOCCC([O-])=O | 1g | 761707322

Hydroxy-PEG1-acid sodium salt | Broadpharm | 2855229-28-4156.113 | C5H9NaO4 | 0.000 | [Na+].OCCOCCC([O-])=O | 1g | 761707322

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Medchemexpress LLC m-PEG5-succinimidyl carbonate | 1058691-00-1 | MFCD30828680 | 98.0% | 393.39 g/mol | C16H27NO10 | 100 MG

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m-PEG5-succinimidyl carbonate is a non-cleavable, 5-unit polyethylene glycol (PEG) succinimidyl carbonate linker with an NHS-type carbonate reactive group for conjugation to primary amines. It is commonly used in synthesis of antibody-drug conjugates (ADCs), PROTAC linkers, and for PEGylation of amine-containing molecules. Typical specifications: purity 98.0%, molecular weight 393.39 g/mol, formula C16H27NO10, CAS 1058691-00-1.

• Provides an NHS-type carbonate reactive group for efficient amine conjugation.
• Non-cleavable 5-unit PEG spacer increases solubility and spacing between conjugated moieties.
• High purity (98.0%) suitable for research-grade conjugation chemistry.
• Available in small pack sizes to support synthetic workflows.
• Stable when stored frozen; follow solvent storage recommendations for solutions.

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Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 1559.62 | C74H98N10O27 | 5 MG

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Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable antibody-drug conjugate (ADC) drug-linker conjugate that couples a maleimide-PEG4 linker to the cytotoxic payload DMEA-PNU-159682 for use in ADC research and synthesis. It is supplied in small milligram pack sizes for preclinical research applications.

• Cleavable maleimide-PEG4 linker enabling thiol conjugation.
• Valine-citrulline (vc) dipeptide linker with PABC self-immolative spacer.
• Includes DMEA-PNU-159682 cytotoxic payload for ADC development.
• Supplied as a small-scale mg quantity suitable for research use.
• Molecular weight 1559.62 and molecular formula C74H98N10O27.
• CAS number 2259318-52-8 for unambiguous identification.

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Broadpharm t-Boc-N-amido-PEG4-(CH2)3CO2H | 1416777-48-4 | MFCD27977493 | 100mg

t-Boc-N-amido-PEG4-(CH2)3CO2H | Putity: 98% | MW: 379.5 | 1416777-48-4 | MFCD27977493 | 100mg

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eMolecules​ 1599472-25-9 | Mal-PEG6-NHS ester | Broadpharm | MFCD20926374 | 530.527 | C23H34N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 250mg | 208572696

Mal-PEG6-NHS ester | Broadpharm | 1599472-25-9 | MFCD20926374 | 530.527 | C23H34N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 250mg | 208572696

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eMolecules​ 182244-33-3 | Bromoacetamido-PEG2-Boc-amine | Broadpharm | MFCD28142467 | 369.256 | C13H25BrN2O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCNC(=O)CBr | 1g | 296213749

Bromoacetamido-PEG2-Boc-amine | Broadpharm | 182244-33-3 | MFCD28142467 | 369.256 | C13H25BrN2O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCNC(=O)CBr | 1g | 296213749

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eMolecules​ 1343476-41-4 | Acid-PEG5-NHS ester | Broadpharm | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 550804100

Acid-PEG5-NHS ester | Broadpharm | 1343476-41-4 | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 550804100

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Medchemexpress LLC HY-128767 5mg Medchemexpress, VH032-PEG3-acetylene CAS:2098799-80-3 Purity:>98%

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Medchemexpress, HY-128767 5mg VH032-PEG3-acetylene CAS:2098799-80-3 VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Medchemexpress LLC DBCO-PEG2-acid | 2304558-25-4 | >=95.0% | C26H28N2O6 | 50 MG

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DBCO-PEG2-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs themselves are composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, allowing PROTACs to exploit the intracellular ubiquitin-proteasome system for selective protein degradation.

• PEG-based PROTAC linker
• Used in PROTAC synthesis
• Click chemistry reagent
• Features a DBCO group for SPAAC
• Reacts with azide-containing molecules
• Exploits the ubiquitin-proteasome system
• Selectively degrades target proteins

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eMolecules​ DBCO-PEG5-TFP Ester | Broadpharm |744.737 | C38H40F4N2O9 | 0.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c1F | 10mg | 795362010

DBCO-PEG5-TFP Ester | Broadpharm |744.737 | C38H40F4N2O9 | 0.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c1F | 10mg | 795362010

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Medchemexpress LLC 3,6,9,12-tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate) | 875770-32-4 | 99.3% | 386.46 | C18H26O7S | 250 MG

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Propargyl-PEG4-Tos is a PEG-based linker used as an alkyne click-chemistry reagent and cleavable linker for PROTAC and antibody-drug conjugate synthesis. It provides a hydrophilic PEG4 spacer to improve solubility and enable CuAAC functionalization.

• Click chemistry alkyne for copper-catalyzed azide-alkyne cycloaddition
• Cleavable ADC and PROTAC linker functionality
• PEG4 spacer increases hydrophilicity and solubility
• Confirmed identity by 1H NMR and LCMS
• High purity (HPLC 99.3%)

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