Immunohistochemistry Kits and Reagents
ABclonal Technology Phospho-SQSTM1/p62-S349 Rabbit pAb
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Biocare Medical, LLC Background Sniper - 500 ml
Background Sniper is specifically formulated for superior pH stability and is sodium azide and thimerosal free. It is a universal blocking reagent used for reducing nonspecific background staining often found with immunohistochemistry, ELISA, immunoelectron microscopy and immunogold techniques. Casein has proven to be a superior blocking reagent as compared to serum proteins. It can also be used on an automated staining system.
Biocare Medical, LLC DAB Away, Removes Residual DAB Stain that May Clog Instrument Probes and Tubing, 250 ml
Contamination with diaminobenzidine (DAB) residue can be a problem that may affect staining quality on automated immunohistochemistry stainers. In most cases, bleach simply reduces the color intensity; whereas, DAB Away removes the residual DAB stain that may clog instrument probes and tubing. This three-component kit will prepare 250 milliliters of cleaning solution. DAB Away is designed to work on Biocare's Nemesis, and intelliPATH automated stainers. DAB Away can also be used with Dako's Autostainer, Autostainer Plus and Autostainer Plus Link instruments as well as Lab Vision's Autostainer 360, 480 and 720 models.
ABclonal Technology Phospho-p38 MAPK-T180/Y182 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
ABclonal Technology IGF2BP1/IMP1 Rabbit pAb
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
Medchemexpress LLC CDH16 Human HEK293 50ug
CDH16 a calcium-dependent cell adhesion protein belongs to the cadherin family It exhibits homophilic interactions potentially contributing to cell-type sorting and regulating cell-cell adhesions for cellular organization CDH16 Protein Human (HEK293 His) is the recombinant human-derived CDH16 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC DDR1 protein, human (HEK293, His) | >95.0% | 50 UG
DDR1 protein is the recombinant extracellular domain of human Discoidin Domain Receptor 1, produced in HEK293 mammalian cells and supplied with a C-terminal His tag as a lyophilized preparation for research use. It is suitable for binding studies, antibody characterization, and assay development, and is provided with purity and handling information in the accompanying documentation.
- Recombinant extracellular domain of human DDR1 expressed in HEK293 cells.
- Supplied with a C-terminal His tag for detection or purification.
- Lyophilized formulation with trehalose for stability during storage.
- Purity greater than 95% by SDS-PAGE.
- Molecular weight approximately 55-70 kDa, extracellular domain D21-T416.
- Store frozen; aliquot and avoid repeated freeze-thaw cycles.
ABclonal Technology KO Validated Claudin 1
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet with complementary grooves in the inwardly facing extracytoplasmic leaflet The protein encoded by this gene a member of the claudin family is an integral membrane protein and a component of tight junction strands Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome
Vector Laboratories ImmPRESS-HRP Anti-Mouse IgG (Horseradish Peroxidase) Polymer Detection Kit, Made In Goat 50 ml
The ImmPRESS-HRP Anti-Mouse IgG (Peroxidase) Polymer Detection Kit is made in goat and targets mouse primary antibodies. This IHC staining system uses novel conjugation chemistry to create a highly sensitive, ready-to-use, one-step, biotin-free detection system. (A combination of highly active enzyme (peroxidase or alkaline phosphatase) and affinity-purified secondary antibodies results in crisp, strong staining. The ImmPRESS™ micropolymer technology minimizes steric interference and provides enhanced accessibility to the primary antibody targets. The IHC immunostaining protocol is simple. Following a blocking step with 2.5% goat serum, sections are incubated with primary antibody. After a brief wash, the appropriate ImmPRESS™ Reagent is added to the sections and incubated for 30 minutes. Sections are again rinsed and the slides are developed with a peroxidase or alkaline phosphatase substrate. The ImmPRESS Reagent is ready-to-use and stains 250-500 sections.
ABclonal Technology SFRP1 Rabbit mAb
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling, epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
ABclonal Technology TDP-43/TARDBP Rabbit pAb
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
ABclonal Technology TDP-43/TARDBP Rabbit pAb
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Cell Signaling Technology FoxP3/Transcription Factor Fixation/Permeabilization Concentrate (4X) 50 ml
FoxP3/Transcription Factor Fixation/Permeabilization Concentrate (4X) 50 ml
ABclonal Technology Phospho-p38 MAPK-T180 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Leica Biosystems BLUE CHROMOGEN
Blue Chromogen is designed to be used in conjunction with DS9914 BOND Polymer Refine HRP Plex Detection kit. This chromogen provides a vibrant blue color and is suitable for use with aqueous mounting media. Our Blue Chromogen provides brilliant contrast against other chromogens and counterstains including hematoxylin. Take advantage of on-board chromogen mixing on BOND instruments, not to mention the fully automated staining opportunities using BOND detection systems and BOND ready-to-use primary antibodies and probes.