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ATX inhibitor 11 is a research-grade small-molecule autotaxin (ATX) inhibitor with reported IC50 of 2.7 nM. Supplied as a high-purity powder for in vitro and in vivo studies, it has documented solubility in DMSO and defined cold-storage recommendations. The compound is used in preclinical fibrosis models, including lung fibrosis, to reduce α-SMA deposition.
High potency against autotaxin (IC50 2.7 nM).
High purity suitable for research applications.
Soluble in DMSO at 100 mg/mL with ultrasonic assistance.
Stable powder with defined cold-storage conditions.
Validated in preclinical fibrosis models to reduce α-SMA deposition.
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HC-Toxin is a cyclic tetrapeptide that acts as a potent HDAC inhibitor with an IC50 of 30 nM. It is known to induce tumor cell apoptosis and exhibits anticancer effects. This compound demonstrates potent antiproliferative efficacy and causes cell cycle arrest at G2/M in T47D human breast cancer cells in a dose-dependent manner.
Potent HDAC inhibitor (IC50 = 30 nM)
Induces tumor cell apoptosis
Exhibits anticancer effects
Demonstrates antiproliferative efficacy
Causes cell cycle arrest at G2/M in T47D human breast cancer cells
Active in HeLa cells with an IC50 = 430 nM for inhibitory activity against histone deacetylase enzyme
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An ionizable cationic lipid (pKa = 6.38); has been used in the generation of LNPs for the delivery of siRNA; intravenous administration of LNPs containing ATX-100 and encapsulating Factor VII siRNA decrease Factor VII blood levels in mice
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Cholera toxin B subunit (CTB) binds GM1 ganglioside Fluorescent CTB is used to label lipid rafts and as a neuronal retrograde tracer Biotiums CF dyes have superior brightness and photostability compared to other dyes Near-infrared CF790 dye has Ex/Em at 783/808 nm 100 ug
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