General Cell Based Assays
Eurofins Discoverx cAMP Hunter eXpress ADRB3 DLD1 GPCR Assay, 2-Plate Kit. (95-0182E13CP25M)
The cAMP Hunter ADRB3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. isoproterenol) based activation of ADRB3 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADRB3, a naturally Gs coupled GPCR. Upon activation of ADRB3, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical Glycogen FluorometrIc Detecto
A GnRH receptor antagonist (Kis 6 2.2 and 3.8 nM for the human mouse and rat receptors respectively) selective for the GnRH receptor over a panel of 43 receptors ion channels and enzymes at 1 UM prevents GnRH-induced increases in inositol phosphate production in HEK293 cells expressing the human GnRH receptor (KB 25 nM) oral or intravenous administration decreases plasma LH levels in castrated rats inhibits GnRH-A-induced increases in plasma LH and testosterone levels in non-castrated rats at 20 mg/kg
ILEX LIFE SCIENCES LLC QUICKZYME HUM MMP14 4X96 ASSAY
QuickZyme Human MMP-14 Activity Assay Kit, 4 x 96 Assays, 96-well plate format, immunoassay for active matrix metalloproteinase 14 (cell extracts, tissue homogenates, tissue extracts samples). The QuickZyme Human MMP-14 Activity Assay is an enzyme activity immunoassay that enables quantitative measurement of active human matrix metalloproteinase-14 in cell extracts, tissue homogenates, or tissue extract samples. This 96-well plate format assay is based on the QuickZyme technology, using a modified pro-enzyme as a substrate, which upon activation is able to release color from a chromogenic peptide substrate. This amplification step provides a unique assay sensitivity. ASSAY RANGE: 0.1 - 16 ng/ml. SENSITIVITY: 0.5 ng/ml (2 h incubation); 0.1 ng/ml (5 h incubation). SYNONYMS: MMP14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP.
BIOMEDICAL RESEARCH CENTER (BRSC) PYRUVATE KINASE (PK) ASSAY KIT
Pyruvate Kinase (PK) Assay Kit (100 assays)
American Research Products Inc Adalimumab Biosimilar
Adalimumab Biosimilar (Anti-TNFa) Antibody is a biosimilar antibody with human reactivity produced in homo sapiens Available in 100 ug size with 7 - 14 business days lead time Ships via gel pack Store at -20 C to -80 C for 12 months in lyophilized form After reconstitution if not intended for use within a month aliquot and store at -80 C (Avoid repeated freezing and thawing) Lyophilized antibodies are shipped at ambient temperature
Cayman Chemical BIlIvRdIn Reductase Bhumn 50ug
Source: Active recombinant human biliverdin reductase B expressed in E. coli • Amino acids: 1-206 (full length) • MW: 22 kDa
Cayman Chemical Cel-Based asy Glucose OxId 2mg
An ionizable cationic lipid (pKa 6.5) has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume lung metastatic nodule numbers and lung levels of CD4 and CD8 T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis the same LNPs decrease the number of Tregs increase the number of tumor-associated M1 macrophages and increase intratumoral levels of Il-12 Il-2 Tnf-a and Ifn-? in a B16/F10 murine melanoma model