General Cell Based Assays
Eurofins Discoverx PathHunter eXpress IL5RA/CSF2RB Dimerization Assay, 2pl Kit. (93-0972E3CP0M)
The PathHunter IL5RA/CSF2RB Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-5) induced dimerization of IL5RA/CSF2RB receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside IL5RA target protein fused to EA. Upon ligand-induced dimerization of IL5RA/CSF2RB, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc LANCE Ultra Phospho-AKT1/2/3 (Thr308) Detection Kit, 10,000 Assay Points
LANCE Ultra Phospho-AKT1/2/3 (Thr308) Detection Kit, 10,000 Assay Points
Revvity Health Sciences Inc HTRF Human Phospho-FGFR2 (Tyr653/654) Detection Kit, 500 Assay Points
HTRF Human Phospho-FGFR2 (Tyr653/654) Detection Kit, 500 Assay Points
Eurofins Discoverx PathHunter eXpress CNR1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0959E2CP0L)
The PathHunter CNR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CP 55,940) based activation of CNR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CNR1 and EA-tagged β-Arrestin-2. Activation of CNR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Human & Mouse Total NF-κB Detection Kit, 500 Assay Points
HTRF Human & Mouse Total NF-κB Detection Kit, 500 Assay Points
Revvity Health Sciences Inc HTRF HIV p24 Detection Kit, 500 Assay Points
HTRF HIV p24 Detection Kit, 500 Assay Points
Revvity Health Sciences Inc HTRF Human Phospho-AKT1/2/3 (Ser473) Detection Kit, 500 Assay Points
HTRF Human Phospho-AKT1/2/3 (Ser473) Detection Kit, 500 Assay Points
Cell Biolabs Inc OxiSelect™ DNA Double-Strand Break Staining Kit, Trial Size, 20 assays
DNA double-strand breaks (DSBs) are probably the most dangerous of the many different types of DNA damage that occur within the cell. A very early step in the cellular response to DSBs is the phosphorylation of a histone H2A variant, H2AX, at the sites of DNA damage. H2AX is rapidly phosphorylated (within seconds) at serine 139 when DSBs are introduced into mammalian cells resulting in discrete γ-H2AX (phosphorylated H2AX) foci at the DNA damage sites. Phosphorylation of H2A at serine 139 causes chromatin decondensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the sites of DNA damage. Cell Biolabs’ OxiSelect™ DNA DSB Staining Kit is based on the phosphorylation of the histone H2A.X at serine 139 in response to DNA damaging agents which cause double strand breaks in cells that are cultured in microtiter plates. This Trial Size kit provides sufficient reagents for up to 20 stainings in a 96-well plate.
Revvity Health Sciences Inc HTRF Human Phospho-RIPK1 (Ser166) Detection Kit, 500 Assay Points
HTRF Human Phospho-RIPK1 (Ser166) Detection Kit, 500 Assay Points
Revvity Health Sciences Inc HTRF Human & Mouse Total CDK2 Detection Kit, 500 Assay Points
HTRF Human & Mouse Total CDK2 Detection Kit, 500 Assay Points
Eurofins Discoverx PathHunter Human TYK2 Kinase Activity Cell-Based Assay Kit (U2OS)
The PathHunter Human TYK2 Stable Cell Line Kinase Activity Assay (U2OS) measures TYK2 CTK activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
