General Cell Based Assays
FOCUS BIOMOLECULES Biochemical Reagents, LXG6403, Lysyl oxidase inhibitor, CAS 315705-04-5, 98% by TLC/NMR (Conforms)
Biochemical Reagents, LXG6403, Lysyl oxidase inhibitor, CAS 315705-04-5, 98% by TLC/NMR (Conforms), LXG6403 is a potent (IC50 1.3 uM) and selective (3.5x over LOXL2 and no inhibition of LOX1) lysyl oxidase (LOX) inhibitor. Active against LOX in multiple cell lines (IC50 less than5 uM against MDA-MB-231, HCC143, Hs-578-T, and HCC1937). LXG6403 enhanced chemosensitivity of triple negative breast cancer cells to anthracycline, doxorubicin, cisplatin, and paclitaxel. It inhibited collagen crosslinking and deposition, increased doxorubicin penetration in cells and organoids, inhibited FAK signaling, and potentiated ROS/DNA damage axis in combination with cisplatin. LXG6403 was able to overcome doxorubicin resistance in the TM01278 TNBC PDX model.
American Research Products Inc Canine acetylcholine receptor
Canine acetylcholine receptor antibody AChRab ELISA Kit from CUSABIO Detection Range 3 75 ng/mL-240 ng/mL Sensitivity 0 94 ng/mL Sample serum plasma Method Sandwich
Meso Scale Discovery U-PLEX Human IL-17A/F ASY
The Meso Scale Discovery U-PLEX Human IL-17A/F Assay Kit is a multiplex immunoassay that measures human interleukin 17A and interleukin 17F in cell culture supernatants serum plasma and other biological samples This electrochemiluminescent assay utilizes MSD s proprietary SECTOR Imager and provides high sensitivity a broad dynamic range and requires low sample volume The kit includes a 96-well plate coated with capture antibodies detection antibodies Read Buffer Diluent 2 Calibrator Blend and Wash Buffer It can detect IL-17A in a range of 0 06-1500 pg/mL and IL-17F in a range of 0 10-1500 pg/mL
Enzo Life Sciences CV-Cathepsin K detection kit (1 Kit)
Elevated cathepsin enzyme activity often indicates the presence of a pathological condition including cancer, Alzheimer's disease, autoimmune disease, and osteoporosis. Based on the dye cresyl violet and the cathepsin K LeuArg peptide recognition sequence, this kit allows the detection of cathepsin K activity in living cells by fluorescence microscopy. Once cells are grown, staining is completed in just a few minutes. Hoechst 33342 stain and Acridine Orange are also included to allow visualization of nuclei and lysosomes. Applications: Fluorescence microscopy, Fluorescent detection .
Medchemexpress LLC Pertuzumab, 10mg | CAS No. : 380610-27-5
Pertuzumab, a humanized IgG1 monoclonal antibody, is a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer.