Protein Purification
Apexbio Technology LLC Calpain Inhibitor II, ALLM, 5mg. Cas: 136632-32-1 MFCD: NA. Calpain inhibitor
Calpain inhibitor. Calpain Inhibitor II, ALLM 5mg. 136632-32-1.
Enzo Life Sciences Ac-DEVD-AMC (5 mg)
Caspase substrate. Fluorogenic substrate for caspase-3 with Km=9.7µM. Also a substrate for caspase-1, -4, -7 and -8. The peptide sequence is based on the PARP cleavage site Asp216 for caspase-3. Ex.: 340-360nm, Em.: 440-460nm. Alternative Name: Caspase 3 substrate (fluorogenic). Formula: C30H37N5O13. MW: 675.7. Formulation: Lyophilized. Purity: ≥97% (HPLC). Sequence Ac-Asp-Glu-Val-Asp-AMC (AMC = 7-Amino-4-methylcoumarin). Solubility: Soluble in DMSO; dilute with buffer, pH 7.5. Long Term Storage: -20°C. Handling: Protect from light.
Medchemexpress LLC Protein kinase inhibitor 6 | 348-45-8 | 99.04% | C13H9FN2S | 5 MG
Protein kinase inhibitor 6 is a protein kinase inhibitor. This product is for research purposes only and not for patient use.
- Protein kinase inhibitor
- Appearance: solid, white to off-white
- Solubility in DMSO: 125 mg/mL
- For research purposes only
Abcam NCH 51, HDAC inhibitor, 50MG
MW 390.6 Da, Purity >99%. Novel HDAC inhibitor (IC₅₀ values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC₅₀ = 3.8 μM). Also reactivates latent HIV-1 gene expression.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical K-Ras G12C InhIbItr 9 10mg
An irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro
Cayman Chemical Syk InhIbItr 10mg
An oxindole compound that potently blocks Syk activity (IC50 = 14 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change
Medchemexpress LLC IL-17A inhibitor 2 | 2452464-77-4 | 99.9% | 622.50 | 1 MG
IL-17A inhibitor 2 is an IL-17A inhibitor used for researching psoriasis, rheumatoid arthritis, and multiple sclerosis. This product is for research use only and not sold to patients.
- Acts as an IL-17A inhibitor
- Used for researching psoriasis, rheumatoid arthritis, and multiple sclerosis
- Available as a solid
- Color is white to off-white
Abcam ML7, myosin light chain kinase inhibitor, 50MG
MW 452.7 Da, Purity >99%. Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC RBPJ Inhibitor-1 (RIN1) | 2682114-39-0 | 99.9% | 311.31 | 100 MG
RBPJ Inhibitor-1 (RIN1) is the first inhibitor of RBPJ, functioning by blocking the interaction of RBPJ with SHARP. This inhibition suppresses NOTCH-dependent tumor cell proliferation. It is intended for research use only. In laboratory settings, this compound inhibits the proliferation of hematologic cancer cell lines and promotes skeletal muscle differentiation from C2C12 myoblasts.
- Blocks functional interaction of RBPJ with SHARP.
- Suppresses NOTCH-dependent tumor cell proliferation.
- Inhibits proliferation of hematologic cancer cell lines.
- Promotes skeletal muscle differentiation from C2C12 myoblasts.
- Induces formation of multinucleated myofibers.
- Exhibits IC50 of 0.18 μM for Hes1-Luciferase activity in AD-293 cells.
- Shows similar potency and efficacy against NOTCH3 ICD.
Abcam Garcinol, HAT p300 and PCAF inhibitor, 25MG
MW 602.8 Da, Purity >95%. Potent histone acetyltransferase p300 and PCAF inhibitor (IC₅₀ values are 7 and 5 μM for p300 and PCAF respectively). Pleiotropic agent. Strongly inhibits chromatin transcription and induces apoptosis. Inhibits histone acetylation in vivo. Antioxidant and chemoprotective agent.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GSK-J1, H3K27 histone demethylase inhibitor, 10MG
MW 389.4 Da, Purity >99%. Potent and selective H3K27 histone demethylase inhibitor (IC₅₀ = 60 nM, JMJD3). Inhibits UTX. Some activity for the H3K4me3/2/1 demethylases Jarid1b and Jarid1c (IC₅₀ values are 950 nM and 1.76 μM, respectively). No significant inhibitory activity against 100 protein kinases at a concentration of 30 μM. Anti-inflammatory effects.
The product is subject to the following: Abcam Restricted Use Statement
CPC Scientific Biotin-Tyr-Val-Ala-Asp-CMK 0.5MG
Biotinylated analog of the caspase-1 inhibitor.ONE-LETTER SEQUENCE: Biotin-YVAD-CMKMOLECULAR FORMULA: C32H45Cl1N6O9S1MOLECULAR WEIGHT:725.27STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [402474-75-3], SYNONYMS: Biotinyl-Tyr-Val-Ala-Asp-chloromethylketoneRESEARCH AREA: ApoptosisREFERENCES: Y.A. Lazebnik et al., Nature, 371, 346 (1994)
Medchemexpress LLC PARP14 inhibitor H10 | 2084811-68-5 | >98.0% | 557.58 | C24H27N7O7S | 5 MG
PARP14 inhibitor H10 is a selective small-molecule inhibitor of PARP14 used as a research tool to probe PARP14-dependent biology. It inhibits PARP14 with an IC50 of approximately 490 nM and has been reported to induce caspase-3/7-mediated apoptosis in cellular assays.
- Selective PARP14 inhibition (IC50 ≈ 490 nM).
- Approximately 24-fold selectivity over PARP1.
- Induces caspase-3/7-mediated apoptosis in cellular assays.
- High purity suitable for research (reported ≥98%).
- Molecular formula C24H27N7O7S and molecular weight 557.58 g/mol.