Protease Inhibitors and Phosphatase Inhibitors
Cayman Chemical PD-1PD-L1 InhIbItr 2 1mg
Prevents the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM
Cayman Chemical mP-13 InhIbItr 10mg
A pyrimidine dicarboxamide that selectively inhibits MMP-13 (IC50 = 8 nM); blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification
Cayman Chemical K-Ras G12C InhIbItr 12 1mg
An allosteric inhibitor of oncogenic K-Ras(G12C); decreases viability and increases apoptosis in several lung cancer cell lines that contain G12C mutations (EC50 = 0.32 µM in H1792 cells)
Cayman Chemical JNK InhIbItr XVI 1mg
A selective, irreversible JNK inhibitor (IC50s = 4.67, 18.7, and 0.98 nM for JNK1, 2, and 3, respectively); prevents phosphorylation of c-Jun in A375 and HeLa cells (EC50s = 338 and 486 nM, respectively)
Cayman Chemical Syk InhIbItr 10mg
An oxindole compound that potently blocks Syk activity (IC50 = 14 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change
Cayman Chemical STAT5 InhIbItr 5mg
A cell-permeable, nonpetidic nicotinoyl hydrazone that selectively suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity)
Cayman Chemical TIe2 InhIbItr 7 5mg
Blocks Tie2 kinase activity (Ki = 1.3 µM), inhibiting angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling (IC50 = 0.3 µM); prevents endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization
Sigma Aldrich Fine Chemicals Biosciences Sodium phenylbutyrate, 1716-12-7, MFCD00800247, 100 mg
Empirical Formula (Hill Notation): C10H11NaO2, Molecular Weight: 186.18, ≥98% (HPLC), storage temp: room temp, Synonym: 4-PBA, 4-Phenylbutyric acid, 4-phenylbutyrate, Buphenyl, Sodium 4-phenylbutyrate, TriButyrate.
Abcam Phosphatase Inhibitor Cocktail I, 1ML
Phosphatase Inhibitor Cocktail I (ab201112) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Telaprevir (VX-950) 50mg 402957-28-2 LY-570310, MP-424
Telaprevir (VX-950, LY-570310, MP-424) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical Syk InhIbItr 1mg
An oxindole compound that potently blocks Syk activity (IC50 = 14 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change
Cayman Chemical PKR InhIbItr 1mg
Binds the ATP-binding site of PKR and blocks autophosphorylation (IC50 = 186-210 nM); protects neuroblastoma cells against cell damage triggered by ER stress; prevents phosphorylation of FADD, preventing apoptosis; reduces phosphorylation of PKR and eIF2α in the brain, enhancing long-term memory storage
Cayman Chemical EGFRErbB2 InhIbItr 1mg
A cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively); inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 µM)
Cayman Chemical Cdk46 InhIbItr IV 5mg
A cell-permeable triaminopyrimidine that selectively and reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity (IC50s = 1.5 and 5.6 μM, respectively); induces cell cycle arrest in the G1 phase and apoptosis in asynchronous cell lines; suppresses tumor growth in mice bearing human HCT116 colon carcinoma xenografts
Cayman Chemical ADAMTS-5 InhIbItr 500ug
An inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1)