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Cocktails, tablets, capsules, and individual purified formulations of protease inhibitors and phosphatase inhibitors designed to protect proteins from degradation during cell lysis and extraction.
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
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Binds the ATP-binding site of PKR and blocks autophosphorylation (IC50 = 186-210 nM); protects neuroblastoma cells against cell damage triggered by ER stress; prevents phosphorylation of FADD, preventing apoptosis; reduces phosphorylation of PKR and eIF2α in the brain, enhancing long-term memory storage
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
MW 151.17 Da, Purity >95%. Potent, irreversible and specific MPO inhibitor (IC₅₀ = 300 nM). Benzoic acid analog. No inhibition of catalase or glutathione peroxidase activity. Inhibits apoptosis in vitro.
MW 294.4 Da, Purity >98%. Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC₅₀ = 4.1 μM). Binds to the XIAP BIR3 protein and interacts with residues crucial for Smac and caspsase-9 binding. Inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells (IC₅₀ = 3.7 - 5.7 μM); minimal effects on normal prostate cells (IC₅₀ = 19.3 - 20.1 μM). Antitumor and anti-inflammatory effects in vivo.