Protein Purification Reagents and Kits
Medchemexpress LLC RAS/RAS-RAF-IN-1 | 2447039-81-6 | 99.8% | 807.98 | 1 ML
RAS/RAS-RAF-IN-1 is a potent inhibitor of both RAS and RAS-RAF pathways. It demonstrates a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity and exhibits antitumor activity.
- Potent inhibitor of Ras and Raf.
- Exhibits antitumor activity.
- EC50 of 0.5 μM-5.0 μM for BRAF-GTP-KRAS-G12C disruption.
- IC50 of 1.0 μM-10 μM for pERK inhibition in H358 cells.
AdipoGen VISTA msCOMP msrecHis
Protein. The extracellular domain of mouse VISTA aa 33-191 is fused at the C-terminus to the domain of the mouse cartilage oligomeric matrix protein COMP aa 28-72 and a His Tag. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Mouse VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues spleen, thymus and bone marrow and on myeloid cells with lower expression on CD4 and CD8 T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
Cayman Chemical GST GlutathIon 1ea
An NQO1 substrate and a derivative ofBlapachone converted by NQO1 to NAD and increases the ratio of NAD to NADH in a cell-free assay as well as C2C12 and L6 myoblasts at 1 1 or 2 UM respectively increases intracellular ATP levels as well as decreases intracellular lactate and ROS levels in primary fibroblasts isolated from patients with MELAS at 1 UM increases the levels of mitochondrial complex I and mitochondrial complex III as well as increases the OCR in primary fibroblasts isolated from patients with MELAS at 1 UM inhibits cisplatin-induced apoptosis production of mitochondrial ROS and mitochondrial membrane depolarization in primary mouse cochlear organ of Corti cells at 1 UM
Cayman Chemical DL-Sulforaphn GlutathIon 1mg
A metabolite of sulforaphane; increases mRNA expression of GSTA1 and UGT1A1 in HepG2 cells at 15 µM
Cayman Chemical DL-Sulforaphn GlutathIon 5mg
A metabolite of sulforaphane; increases mRNA expression of GSTA1 and UGT1A1 in HepG2 cells at 15 µM
![ABclonal Technology [KO Validated] Glutathione Synthetase (GSS) Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000109035.jpg-250.jpg)
ABclonal Technology [KO Validated] Glutathione Synthetase (GSS) Rabbit pAb
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency.
AdipoGen ANGPTL3 FLD h rec
Recombinant Protein. Fibrinogen-like domain of human ANGPTL3 aa 224-460 is fused at the N-terminus to a FLAG -tag. Source/Host HEK 293 cells. Endotoxin <0.01EU/µg purified protein LAL test. Lyophilized. Contains PBS. ANGPTL3 Angiopoietin-like protein 3 regulates angiogenesis and also directly regulates lipid, glucose and energy metabolism. Angiopoietin-like 3 ANGPTL3 is a regulator of plasma triglyceride TRG levels due to its inhibitory action on the activity of lipoprotein lipase LPL. ANGPTL3 induces angiogenesis by binding to integrin alphavbeta3. ANGPTL3 is predominantly produced in the liver and can therefore be classified as a hepatokine. In the human plasma, ANGPTL3 is cleaved to released two fragments a N-terminal coiled-coil domain-containing fragment aa17-207 important for inhibiting the lipolysis of triglyceride and the C-terminal fibrinogen-like domain-containing fragment aa208-460.
AdipoGen TAPBPL hFc hrec
Recombinant Protein. The extracellular domain of human TAPBPL aa 19-405 is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized. Contains PBS. T cells play critical roles in the adaptive immune system, protecting the human body against cancer, bacterial, viral, fungal and parasitic infections. T cell immune response is tightly controlled by immune checkpoint proteins that negatively or positively regulate T cell response. Among the immune checkpoint proteins, the B7 family plays a key role in controlling immune responses and belongs to the immunoglobulin Ig superfamily. A number of B7 family ligands have been identified, such as B7-1 CD80, B7-2 CD86, PD-L1 B7-H1, PD-L2 B7-DC, B7-H2 inducible T cell co-stimulator ligand ICOS, B7-H3, B7-H4 B7x, B7S1, B7-H5 VISTA and B7- H6. Because of the potential clinical applications of immune checkpoint proteins, there has been intense interest in identifying additional T-cell regulators.
BIOHIPPO Anti-Human BRAF/B-Raf (V600E) Antibody (SAA2068), 100 µg
BRAF/B-Raf (SAA2068) Recombinant Antibody (clone V600E) is a recombinant Mouse IgG2a, kappa antibody specific for BRAF/B-Raf (SAA2068). It reacts with Human. Suitable for ELISA. Recombinant production ensures high specificity and lot-to-lot reproducibility. Supplied as 100 ug.
Ubpbio GLUTATHIONE AGAROSE, 100ML
Protein Purification Reagents – Glutathione Resin (UBPBio catalog# P3060-10, P3060-100) – Glutathione Xpure Agarose Resin consists of glutathione covalently bound to agarose beads. This resin has high binding affinity and specificity to the Glutathione S-transferase (GST) protein. GST-tagged proteins can be highly purified by batch or column purification (low flow rate) in a one step purification method. Bound GST-tagged proteins are easily eluted from the resin with buffers containing reduced glutathione.
Immunology Consultants anti-GST Tag Antibody (Rabbit) - FITC Conjugated
RGST‑45F is a FITC‑conjugated rabbit antibody targeting the GST tag, optimized for fluorescence‑based detection of GST‑tagged recombinant proteins. The fluorescein label provides bright, reliable signal generation in microscopy, flow cytometry, and fluorescent immunoassays. Affinity purification ensures high specificity and low background, supporting clear visualization and consistent assay performance. Produced by Immunology Consultants and supplied in a 1 mg format, RGST‑45F is an excellent choice for researchers requiring a fluorescently labeled anti‑GST reagent for imaging or quantitative fluorescence applications
Immunology Consultants anti-GST Tag Antibody (Rabbit) - Affinity Purified
RGST‑45A is an affinity‑purified rabbit polyclonal antibody specific for the GST (Glutathione S‑Transferase) tag, one of the most widely used fusion tags in recombinant protein expression and purification. The affinity‑purification process enriches high‑specificity immunoglobulins, ensuring strong, selective binding to GST with minimal background across a variety of immunoassay platforms. This reagent is ideal for Western blotting, ELISA, immunoprecipitation, and immunofluorescence applications requiring reliable detection of GST‑tagged proteins. Produced by Immunology Consultants and supplied in a 1 mg format, RGST‑45A provides consistent, high‑quality performance for researchers working with GST fusion constructs, protein expression systems, and tag‑based detection workflows