Cell Line Lysates
American Research Products Inc PrEST Antigen SRD5A1
PrEST Antigen SRD5A1 antigen APrEST85563 for steroid-5-alpha-reductase alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) Recombinant protein fragment of Human SRD5A1
American Research Products Inc PrEST Antigen BRWD1
PrEST Antigen BRWD1 antigen APrEST87031 for bromodomain and WD repeat domain containing 1 Recombinant protein fragment of Human BRWD1
ABclonal Technology ATF6 Rabbit pAb
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
