Cell Line Lysates
Cayman Chemical IkarugamycIn 2.5mg
A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in macrophages; inhibits clathrin-coated pit-mediated endocytosis
Abcam Human AKAP1 knockout HEK-293T cell lysate.
Human AKAP1 knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Phospho-PDHA1-S293 Rabbit pAb
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology TAP2 Rabbit pAb
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
ABclonal Technology CACNB3 Rabbit pAb
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport.
ABclonal Technology MAP3K1 Rabbit pAb
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
Revvity Health Sciences Inc HTRF Human Total MKK4 Detection Kit, Control Lysate
HTRF Human Total MKK4 Detection Kit, Control Lysate
Cayman Chemical AvermectIn B1b 2.5mg
A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants
Revvity Health Sciences Inc HTRF Human Total HER2 Detection Kit, Control Lysate
HTRF Human Total HER2 Detection Kit, Control Lysate
Abcam Human MTMR3 knockout HeLa cell lysate.
Human MTMR3 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement