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A SERD selectively induces degradation of ERa in MCF-7 cancer cells (EC50 0.2 nM) over ERB glucocorticoid androgen progesterone and mineralocorticoid receptors at 5 UM but does activate ERB signaling in reporter cells decreases 17B-estradiol-induced proliferation of MCF-7 cells expressing wild-type ERa MCF-7 cells expressing ERaY537S and MCF-7 cells expressing ERaD538G (EC50s 20 331 and 595 nM respectively) reduces tumor volume in a PDX mouse model of tamoxifen-resistant breast cancer
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