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DSG-PEG 2000 is a PEG-modified lipid that can be used with cationic lipids such as D-Lin-MC3-DMA (No A8791) to prepare cationic nanoparticles (LNP) capable of encapsulating and delivering siRNA mRNA DNA or small molecules into the cytoplasm
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An oxysterol; suppresses endogenous cholesterol synthesis by binding INSIG proteins and preventing SREBPs from being transported to the Golgi; inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM); inhibits replication of SARS-CoV-2 in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection; reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection at 100 mg/kg per day; serum levels are increased in patients with SARS-CoV-2.
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Ultra-pure. Alternative Name: 2,3-Dinor-6-keto-PGF1alpha-d3. Formula: C18H27D3O6. MW: 345.5. Purity: ≥98% (TLC). Appearance: Liquid. Use/Stability: Store, as supplied, at -20°C for up to 1 year. Long Term Storage: -20°C
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Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16,{2626} or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine.{240,2098} Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway{939} or selective acylation with arachidonic acid by a CoA-independent transacylase.{2101}
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Lyso-PAF C-18 can be formed by either the action of PAF-AH on PAF C-18{2626} or by the action of a CoA-independent transacylase on 1-O-octadecyl-2-acyl-glycerophosphocholine.{240,2098} Lyso PAF C-18 is a substrate for eitherPAF C-18 formation by the remodeling pathway{939} or selective acylation with arachidonic acid by a CoA-independent transacylase.{2101}
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A synthetic cationic lipid used in the formulation of nucleic acid-lipid particles (LNPs) for research delivery of RNA and DNA. It promotes encapsulation and cellular uptake of nucleic acids when combined with helper lipids and is supplied for laboratory research use only.
Cationic lipid for formulation of nucleic acid-lipid particles.
Facilitates encapsulation and delivery of RNA and DNA.
High purity suitable for research applications.
Powder form, soluble in DMSO for preparation of stock solutions.
Recommended storage at -20°C to maintain stability.
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