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DSPE-PEG (2000)-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. This compound is capable of forming micelles for targeted drug delivery.
Can form micelles for targeted drug delivery
Useful for polyvalent targeted delivery of vinorelbine to cancer cells
Can be used as optical coherence tomography contrast agents for tumor angiography in live animals
Targets liposome
Pathway: Metabolic enzyme/protease
Powder stable at -20°C for 3 years
In solvent stable at -80°C for 6 months, and at -20°C for 1 month
Solubility in H2O: 25 mg/mL (requires ultrasonic treatment)
Solubility in DMSO: 25 mg/mL (requires ultrasonic, warming, and heating to 60°C)
Achieves a clear solution at ≥ 2.5 mg/mL in specific in vivo solvent combinations
For research use only
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
An ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA; has been used in the formation of LNPs; administration of mouse FVII-targeting siRNA in L-319-containing LNPs reduce serum levels of FVII in mice; LNPs containing L-319 in combination with cKK-E12 and encapsulating VZV mRNA encoding gE increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More