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Cayman Chemical ANTIBODY L-319 25mg
Supplier: Cayman Chemical 3505125 MG
An ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA; has been used in the formation of LNPs; administration of mouse FVII-targeting siRNA in L-319-containing LNPs reduce serum levels of FVII in mice; LNPs containing L-319 in combination with cKK-E12 and encapsulating VZV mRNA encoding gE increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles
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