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An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity
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A triacylglycerol; has been found in Kpangnana, Chinese tallow, and cocoa butters; increases the phagocytic function of reticulo-endothelial cells in mice at 5 and 10 mg per animal
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
PEG2000-C-DMG is a pegylated lipid used in the preparation of Onpattro, an investigational RNAi therapeutic agent. Onpattro is hepatically directed and reduces the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA.
Pegylated lipid
Used in the preparation of Onpattro
Onpattro is an investigational RNAi therapeutic agent
Onpattro reduces production of mutant and wild-type transthyretin
Targets 3′ untranslated region of transthyretin mRNA
Suitable for research use only
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More