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An ionizable cationic lipid; has been used in the formation of LNPs; LNPs containing DLin-MC2-DMA and encapsulating siRNA targeting mRNA encoding FVII reduce hepatic levels of FVII in mice (ED50 = 0.6 mg/kg)
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1 2-Distearoyl-sn-glycero-3-phosphorylcholine (DSPC) is a phospholipid used in the synthesis of liposomes and lipid nanoparticle (LNP) systems for research related to mRNA vaccines or drug delivery systems
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DSPE-PEG2000-Maleimide (ammonium) is a PEGylated phospholipid composed of DSPE linked to a polyethylene glycol chain (average MW 2000) terminating in a maleimide group. The maleimide functionality enables selective conjugation to thiol-containing molecules, making this reagent useful for creating functionalized liposomes, nanostructured lipid carriers, and surface-modified nanoparticles. The PEG chain improves colloidal stability and extends circulation time.
Thiol-reactive maleimide end for selective covalent conjugation.
PEG2000 chain increases circulation time and colloidal stability.
Designed for liposome and nanoparticle surface functionalization.
Typically supplied as an ammonium salt white to off-white solid.
High purity suitable for research applications (manufacturer-specified).
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DSG-PEG 2000 is a PEG-modified lipid that can be used with cationic lipids such as D-Lin-MC3-DMA (No A8791) to prepare cationic nanoparticles (LNP) capable of encapsulating and delivering siRNA mRNA DNA or small molecules into the cytoplasm
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Empirical Formula: (Hill Notation) C52H90O25, Molecular Weight: 1115.26, Purity >99%. Façade-EM is a two-dimensional amphiphile with hydrophobic and hydrophilic faces that has superior ability to stabilize integral membrane proteins. This new class of detergents represents a departure from traditional one-dimensional polar-head/nonpolar-tail molecules.
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