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DLin-KC2-DMA is an ionizable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). It produces significant siRNA-mediated gene silencing of GAPDH when bound to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
Ionizable cationic lipid (pKa≈6).
Virtually non-toxic to antigen presenting cells (APCs).
Produces significant siRNA-mediated gene silencing of GAPDH when bound to lipid nanoparticles (LNP).
Can be used in siRNA delivery studies.
High uptake into macrophages and dendritic cells.
Efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway.
Displays almost no toxicity in primary APCs.
Effective in silencing target genes in APCs in vivo (5 mg/kg; i.v.; single).
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
DODMA is a cationic lipid used in the preparation of lipid nanoparticles for drug delivery. Its pH-titratable head group remains neutral at physiological pH for systemic circulation, but protonates in the acidic environment of endosomes, facilitating fusion with the endosome membrane and aiding nucleic acid release.
Cationic lipid
Can be used to prepare lipid nanoparticles
Can be used for drug delivery
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DSPE-PEG2000-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. It is designed to form micelles for targeted drug delivery.
Forms micelles for targeted drug delivery
Pegylated derivative
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