Isotopically Labeled Compounds
Medchemexpress LLC Allopurinol | 315-30-0 | 100.0% | 1 ML
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. It can be used in the research of hyperuricemia and gout. It decreases the expression of HIF-1α and HIF-2α protein. It also shows anti-depressant and anti-nociception activity, and anti-leishmanial effect.
- Potent and orally active xanthine oxidase inhibitor
- Can be used in the research of hyperuricemia and gout
- Decreases the expression of HIF-1α and HIF-2α protein
- Reduces angiogenesis traits of HUVEC cells
- Exhibits anti-depressant activity in mouse models
- Induces anti-nociception activity in mouse models
- Shows anti-leishmanial effect
Medchemexpress LLC Pentoxifylline-d5 | 1185995-18-9 | 99.9% | 100 MG
Pentoxifylline-d5 is the deuterium-labeled Pentoxifylline. Pentoxifylline (BL-191) is an orally active non-selective phosphodiesterase (PDE) inhibitor with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic, and anti-proliferation effects. It is used for research on peripheral vascular disease, cerebrovascular disease, and other conditions involving defective regional microcirculation.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Torsemide-d7 | 1189375-06-1 | 99.77% | 1 MG
Torsemide-d7 is the deuterium-labeled form of Torsemide, an orally active loop diuretic with anti-aldosterone and vasodilatory effects. It can be used in research for heart failure, renal disease, and hepatic cirrhosis. Deuterium substitution in drug molecules serves as a tracer for quantitation during drug development and can affect pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Azathioprine-d3 (BW 57-322-d3) | 2702733-53-5 | 1 MG
Azathioprine-d3 (BW 57-322-d3) is a deuterium labeled version of the immunosuppressive agent Azathioprine. It is an orally active compound that converts in vivo to its active metabolite, 6-mercaptopurine (6-MP). This product is intended for research use only and is not for patient use.
- Exhibits myelosuppressive effects
- Induces apoptosis
- Can be used as a tracer for quantitative analysis
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Metolazone-d7 | 2714484-71-4 | 99.9% | 500 UG
Metolazone-d7 is deuterium labeled Metolazone, primarily used to treat congestive heart failure and high blood pressure. Deuteration, the incorporation of stable heavy isotopes into drug molecules, has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Cephalexin-d5 | 2101505-56-8 | 99.0% | 1 MG
Cephalexin-d5 is deuterium labeled Cephalexin, a potent, orally active, first-generation cephalosporin antibiotic. It works by disrupting the growth of bacterial cell walls, effectively killing gram-positive and some gram-negative bacteria. Cephalexin monohydrate is used in research for conditions like pneumonia, strep throat, and bacterial endocarditis. This product is for research use only.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Pimobendan-d3 | 74150-27-9 | 99.4% | 5 MG
Pimobendan-d3 (UD-CG115-d3) is deuterium labeled Pimobendan (HY-B0204), a selective inhibitor of PDE3 with an IC50 of 0.32 μM. It is intended for research use only and not sold to patients. This compound can be used as a tracer and internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer and internal standard
- Suitable for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium labeled for potential impact on pharmacokinetic and metabolic profiles
- Intended for research use only
Medchemexpress LLC Adenine-13C | 86967-48-8 | 99.1% | 1 MG
Adenine-13C is the 13C labeled Adenine. As 6-Aminopurine, it is a purine and one of the four nucleobases found in the nucleic acid of DNA and RNA. This compound plays a significant role in biochemistry, particularly in cellular respiration, forming both ATP and cofactors (NAD and FAD), and protein synthesis.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Tranexamic acid-d2-1 | 2714435-89-7 | 99.2% | 500 UG
Tranexamic acid-d2-1 is the deuterium labeled Tranexamic acid. Tranexamic acid (Transamin) is an antifibrinolytic that blocks lysine-binding sites of plasmin and elastase-derived plasminogen fragments with an IC50 of 5 mM.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Flubendazole-d3 | 1173021-08-3 | 96.00% | 1 MG
Flubendazole-d3 is a deuterium-labeled version of Flubendazole, a safe and effective anthelmintic agent used in humans, rodents, and ruminants. It demonstrates anticancer activities by inhibiting microtubule function, inducing p53-mediated apoptosis, and arresting the G2/M cell cycle. Deuterium substitution in drug molecules can impact their pharmacokinetic and metabolic profiles.
- Deuterium labeled version of Flubendazole
- Safe and effective anthelmintic agent
- Exhibits anticancer activities via microtubule inhibition
- Induces p53-mediated apoptosis
- Arrests G2/M cell cycle
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis (e.g., NMR, GC-MS, LC-MS)
Medchemexpress LLC D-Glucose-d2 | 18991-62-3 | MFCD00064367 | 99.9% | 50 MG
D-Glucose-d2 is a deuterium-labeled form of D-Glucose. D-Glucose, a monosaccharide, plays a vital role in biology as an important carbohydrate. It acts as a carbohydrate sweetener, a critical component of general metabolism, and a signaling molecule related to cellular metabolic status and biotic and abiotic stress responses.
- Can be utilized as a tracer.
- Can serve as an internal standard for quantitative analysis using methods such as NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, like deuterium, are incorporated into drug molecules for quantitation during drug development processes.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Rimantadine-d4 hydrochloride | 350818-67-6 | 99.0% | 5 MG
Rimantadine-d4 (hydrochloride) is the deuterium-labeled form of Rimantadine hydrochloride. Rimantadine is an orally active inhibitor for M2 protein, blocking hydrogen ion channel activity and preventing virus entry and replication, exhibiting broad-spectrum antiviral activity. Deuteration, involving stable heavy isotopes of hydrogen (deuterium), may influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labeled compound
- Acts as an M2 protein inhibitor
- Blocks hydrogen ion channel activity
- Prevents virus entry and replication
- Exhibits broad-spectrum antiviral activity
- Can be used as a tracer for quantitative analysis
- Functions as an internal standard for NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Glucose-d1-4 | 106032-61-5 | 98.0% | 100 MG
D-Glucose-d1-4 is the deuterium labeled D-Glucose. This monosaccharide is an important carbohydrate in biology, serving as a critical component of general metabolism and a significant signaling molecule for cellular metabolic status and stress response.
- Deuterium labeled D-Glucose
- Important carbohydrate in biology
- Critical component of general metabolism
- Significant signaling molecule
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Glucose-d1 | 56570-89-9 | 99.9% | 5 MG
D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. It is a carbohydrate sweetener and a critical component of general metabolism, serving as a critical signaling molecule. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs. The product is for research use only.
- Application as a tracer.
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeling provides a means for tracing during drug development.
Medchemexpress LLC D-Glucose-d1-4 | 106032-61-5 | 98.0% | 50 MG
D-Glucose-d1-4 is the deuterium labeled D-Glucose, a monosaccharide and important carbohydrate in biology. It serves as a carbohydrate sweetener and plays critical roles in general metabolism, cellular metabolic status, and stress response. This compound is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes of hydrogen and carbon
- Potential to affect the pharmacokinetic and metabolic profiles of drugs