Isotopically Labeled Compounds
Medchemexpress LLC Benzene-2,3,5,6-d4-sulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)- | 1020719-86-1 | 99.3% | 5 MG
Sulfamethoxazole-d4 (Ro 4-2130-d4) is a deuterium-labeled version of Sulfamethoxazole, a sulfonamide antibiotic with broad antibacterial activity. It inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (PABA) to affect dihydropteroate synthetase and dihydropteroate reductase. This compound is used in research for conditions such as urinary tract infections (UTIs), prostatitis, and bronchitis. Deuterium labeling incorporates stable heavy isotopes into the drug molecule, which can serve as a tracer for quantitation during drug development and potentially affect pharmacokinetic and metabolic profiles.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Amantadine-d6 | 1219805-53-4 | 98.1% | 5 MG
Amantadine-d6 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits various ion channels, including NMDA and M2, as well as Coronavirus ion channels. It also exhibits anti-orthopoxvirus and anticancer activities. Amantadine-d6 can serve as a tracer and an internal standard for quantitative analysis, with deuteration potentially influencing pharmacokinetic and metabolic profiles of drugs. Applications include research for Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes incorporated into drug molecules for quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Ketotifen-d3 (fumarate) | 1795138-23-6 | 99.23% | 25 MG
Ketotifen-d3 (fumarate) is the deuterium labeled form of Ketotifen fumarate. This compound acts as a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is primarily used to prevent asthma attacks and is intended for research purposes only.
- Deuterium labeled compound
- Functions as a noncompetitive H1-antihistamine
- Acts as a mast cell stabilizer
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis (e.g., NMR, GC-MS, LC-MS)
Medchemexpress LLC Tolbutamide-d9 | 1219794-57-6 | 99.0% | 1 MG
Tolbutamide-d9 is a deuterium-labeled Tolbutamide. Tolbutamide is classified as a first-generation potassium channel blocker and a sulfonylurea oral hypoglycemic agent. This compound can be used as a tracer or an internal standard for quantitative analysis.
- Used as a tracer in drug development
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC D-Glucose-d1-4 | 106032-61-5 | 98.0% | 50 MG
D-Glucose-d1-4 is the deuterium labeled D-Glucose, a monosaccharide and important carbohydrate in biology. It serves as a carbohydrate sweetener and plays critical roles in general metabolism, cellular metabolic status, and stress response. This compound is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes of hydrogen and carbon
- Potential to affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Erythromycin-d3 | 959119-26-7 | 95.0% | 1 MG
Erythromycin-d3 is a deuterium-labeled macrolide antibiotic produced by the actinomycete Streptomyces erythreus. It exhibits broad-spectrum antimicrobial activity by binding to bacterial 50S ribosomal subunits, thereby inhibiting RNA-dependent protein synthesis. Beyond its antibiotic properties, Erythromycin also demonstrates antitumor and neuroprotective effects in various research areas.
- Can be utilized as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Piperidin-4-ol-d9 | 1219799-39-9 | 110.20 | 5 MG
Piperidin-4-ol-d9 is the deuterium labeled Piperidin-4-ol. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Isovaleric acid-d2 | 95927-02-9 | 99.5% | 104.14 | 50 MG
Isovaleric acid-d2 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and is known to affect neonatal death and possible Jamaican vomiting sickness in humans. This compound can be used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes have been incorporated into drug molecules largely as tracers for quantitation during the drug development process, and deuteration has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Stable isotope-labeled compound
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Potential to affect pharmacokinetic and metabolic profiles of drugs due to deuteration
- High purity
Medchemexpress LLC Isoquinoline-d7 | 17157-12-9 | 98.0% | 136.21 | 25 MG
Isoquinoline-d7 is the deuterium labeled Isoquinoline. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline, have anti-cancer activities. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Isovaleric acid-d2 | 95927-02-9 | 99.49% | 104.14 | 25 MG
Isovaleric acid-d2 is the deuterium labeled Isovaleric acid, a natural fatty acid known to affect neonatal death and possible Jamaican vomiting sickness in humans.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 2-pyrrolidinone, 1-methyl-5-(3-pyridinyl-2,4,5,6-d4) | 350818-68-7 | 99.6% | 25 MG
(Rac)-Cotinine-d4 is the deuterium labeled (Rac)-Cotinine. It is for research use only and not sold to patients. This compound is used as a tracer and as an internal standard for quantitative analysis. Deuteration, which incorporates stable heavy isotopes into drug molecules, can affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can impact the pharmacokinetic and metabolic profiles of pharmaceuticals
Medchemexpress LLC Nonanoic acid-d17 | 130348-94-6 | 25 MG
Nonanoic acid-d17 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. It significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Rhamnose-13C-2 monohydrate | 478511-54-5 | 183.16 | 1 MG
Rhamnose-13C-2 (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
Medchemexpress LLC Adamantane-d16 | 30470-60-1 | 5 MG
Adamantane-d16 is the deuterium labeled Adamantane. Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. It can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and can also serve as an anchor in the lipid bilayer of liposomes. It may be used in research of surface recognition and drug delivery. Deuteration has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs by incorporating stable heavy isotopes into drug molecules for quantitation during the drug development process.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS