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Apexbio Technology LLC Sphingosine-1-phosphate 26993-30-6 25mg
Supplier: Apexbio Technology LLC B670725
Sphingosine-1-phosphate (CAS 26993-30-6) is an endogenous signaling lipid functioning as a second messenger and ligand for the G-protein-coupled receptor S1PR1 (also called EDG1) It modulates diverse cellular processes including proliferation survival migration and vascular morphogenesis via activation of downstream pathways such as ERK-1/2 kinase and Gi protein-mediated signaling In cell-based assays S1P exhibits high-affinity binding (Kd 8 1 nM) to S1PR1 and induces calcium mobilization with an EC50 of approximately 2 nM Due to its roles in platelet function cell survival and vascular biology S1P is widely investigated in cell signaling research and therapeutic development
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