Capillary Electrophoresis Systems and Accessories
Sigma Aldrich Fine Chemicals Biosciences PKH67 Green fluorescent Ce
PKH67 kit is for general cell membrane labeling. It has a longer aliphatic carbon tail than PKH1 and PKH2 two other green dyes previously described for in vitro and in vivo cell tracking. Based on the longer tail length in-house studies have consistently shown reduced cell-cell transfer for PKH67 as compared to PKH2.Slow loss of fluorescence has been observed in in vivo studies using PKH1 and PKH2. PKH67 may exhibit similar properties since this behavior appears to be characteristic of green cell linker dyes but not red cell linker dyes. Correlation of in vitro cell membrane retention with in vivo fluorescence half life in non-dividing cells predicts an in vivo fluorescence half life of 10-12 days for PKH67. Other green cell linker dyes with similar half lives have been used to monitor in vivo lymphocyte and macrophage trafficking over periods of 1-2 months suggesting that PKH67 will also be useful for in vivo tracking studies of moderate length.
Microsolv Technology Corporation Capillary Fused Silica 50Um
Capillary, Bare Fused Silica, 50um ID by 1 meter. Simplus Brand. 1/EA.
Medchemexpress LLC DDP-38003 (trihydrochloride) | 459.84 | 5 MG
DDP-38003 (trihydrochloride) | 459.84 | 5 MG
Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 5 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. This compound is for research use only. It exhibits in vivo efficacy after oral administration, determining increased survival in mouse leukemia models with evidence of KDM1A inhibition. It is a potential oral anticancer agent.
- Targets histone demethylase.
- Inhibits KDM1A with an IC50 of 84 nM.
- More active in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue.
- Exhibits in vivo efficacy after oral administration.
- Half-life is 8 hours.
- Significant dose-dependent increase in mice survival.
- Survival rate increases 35% and 62% at doses of 11.25 mg/kg and 22.50 mg/kg, respectively.