Capillary Electrophoresis Systems and Accessories
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Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 5 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. This compound is for research use only. It exhibits in vivo efficacy after oral administration, determining increased survival in mouse leukemia models with evidence of KDM1A inhibition. It is a potential oral anticancer agent.
- Targets histone demethylase.
- Inhibits KDM1A with an IC50 of 84 nM.
- More active in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue.
- Exhibits in vivo efficacy after oral administration.
- Half-life is 8 hours.
- Significant dose-dependent increase in mice survival.
- Survival rate increases 35% and 62% at doses of 11.25 mg/kg and 22.50 mg/kg, respectively.
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