Borinic Acid Derivatives
Medchemexpress LLC HY-W009724 5mg Medchemexpress, 2-Aminoethyl diphenylborinate CAS:524-95-8 Purity:>98%
Medchemexpress, HY-W009724 5mg 2-Aminoethyl diphenylborinate CAS:524-95-8 2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical 2-Aminoethyl Diphenylborinate
A modulator of intracellular calcium levels and TRP channels; inhibits IP3-induced calcium release in rat cerebellar microsomes (IC50 = 42 µM) without affecting IP3 binding to its receptor; inhibits SOCE in DT40 cells (IC50 = 4.8 µM); inhibits TRPC6 and TRPM8 in vitro; activates TRPV1, TRPV2, and TRPV3 in vitro; inhibits thapsigargin-induced calcium transients in DDT1 MF-2 cells at 75 µM; inhibits differentiation of primary mouse brown adipocytes at 30-300 µM and reduces adipocyte triglyceride levels at 100 µM; reduces protein levels of TRPM2 in the rat hippocampus and improves learning and memory deficits induced by amyloid-β (25-35) in rats at 10 mg/kg
Cayman Chemical 2-Aminoethyl Diphenylborinate
A modulator of intracellular calcium levels and TRP channels; inhibits IP3-induced calcium release in rat cerebellar microsomes (IC50 = 42 µM) without affecting IP3 binding to its receptor; inhibits SOCE in DT40 cells (IC50 = 4.8 µM); inhibits TRPC6 and TRPM8 in vitro; activates TRPV1, TRPV2, and TRPV3 in vitro; inhibits thapsigargin-induced calcium transients in DDT1 MF-2 cells at 75 µM; inhibits differentiation of primary mouse brown adipocytes at 30-300 µM and reduces adipocyte triglyceride levels at 100 µM; reduces protein levels of TRPM2 in the rat hippocampus and improves learning and memory deficits induced by amyloid-β (25-35) in rats at 10 mg/kg
Selleck Chemical LLC 2-APB
2-APB (2-Aminoethyl Diphenylborinate) is an IP3 receptor inhibitor and regulate IP3-induced calcium release 2-APB also inhibits the SOC channel activity and inhibits TRP channel at higher concentrations