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Cayman Chemical 2-Aminoethyl Diphenylborinate
Supplier: Cayman Chemical 649705 G
A modulator of intracellular calcium levels and TRP channels; inhibits IP3-induced calcium release in rat cerebellar microsomes (IC50 = 42 µM) without affecting IP3 binding to its receptor; inhibits SOCE in DT40 cells (IC50 = 4.8 µM); inhibits TRPC6 and TRPM8 in vitro; activates TRPV1, TRPV2, and TRPV3 in vitro; inhibits thapsigargin-induced calcium transients in DDT1 MF-2 cells at 75 µM; inhibits differentiation of primary mouse brown adipocytes at 30-300 µM and reduces adipocyte triglyceride levels at 100 µM; reduces protein levels of TRPM2 in the rat hippocampus and improves learning and memory deficits induced by amyloid-β (25-35) in rats at 10 mg/kg
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